Phenotypes associated with this allele

• Allele Symbol: Sftpa1^tm1Haw
• Allele Name: targeted mutation 1, Samuel Hawgood
• Allele ID: MGI:2677859
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sftpa1^tm1Haw/Sftpa1^tm1Haw	involves: 129/Sv * C57BL/6 * CD-1	MGI:2677919

Genotype
MGI:2677919

hm1

• Allelic Composition: Sftpa1^tm1Haw/Sftpa1^tm1Haw
• Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cytokine level ( J:86024 )

abnormal interferon level ( J:86024 )

• IFN-gamma muted response but increased in levels at day 6 after infection

• mRNA increases seen at day 2 after infection

abnormal interleukin level ( J:86024 )

• muted response but increased levels at day 6 after infection

• mRNA increases seen at day 2 after infection

abnormal inflammatory response ( J:85432 )

• KGF induced down regulation of T cell-dependent inflammatory responses fail

• persistent lung inflammation impairs survival after allogeneic bone marrow transplant

increased susceptibility to Orthomyxoviridae infection ( J:86024 )

• when challenged with a mutated influenza A virus, mice exhibited lower LD50 and lost weight with higher mean viral titers at day 2 and 6 of infection

respiratory system

abnormal pulmonary alveolar parenchyma morphology ( J:86024 )

• alveolar parenchyma more edematous and congested with a greater number of inflammatory cells in the airspace lumen on day 6 after influenza A virus infection

abnormal respiratory system physiology ( J:86024 )

• missing an intact epithelial layer after influenza A virus infection

• increased epithelial airway injury at day 6

• alveolar parenchyma more edematous and congested

• clearance response for lipid surfactant due to hyperventilation blunted

increased lung compliance ( J:85432 )

• increased lung compliance when treated with KGF

abnormal surfactant physiology ( J:86024 )

• clearance response for lipid surfactant due to hyperventilation blunted

homeostasis/metabolism

abnormal cytokine level ( J:86024 )

abnormal interferon level ( J:86024 )

• IFN-gamma muted response but increased in levels at day 6 after infection

• mRNA increases seen at day 2 after infection

abnormal interleukin level ( J:86024 )

• muted response but increased levels at day 6 after infection

• mRNA increases seen at day 2 after infection