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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ern2tm1Dron
targeted mutation 1, David Ron
MGI:2677494
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ern2tm1Dron/Ern2tm1Dron either: 129S6/SvEvTac-Ern2tm1Dron or B6.129S6-Ern2tm1Dron MGI:3687738


Genotype
MGI:3687738
hm1
Allelic
Composition		 Ern2tm1Dron/Ern2tm1Dron
Genetic
Background		 either: 129S6/SvEvTac-Ern2tm1Dron or B6.129S6-Ern2tm1Dron
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ern2tm1Dron mutation (0 available); any Ern2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
increased susceptibility to induced colitis ( J:67934 )
• development of intestinal inflammation occurs 3-5 days earlier when challenged with dextran sulfate than in controls
• more severe weight loss (28% vs 9% in controls)
• mortality also more rapid
• lesions more persistent into recovery period
• pathological changes most obvious in the distal large intestine including a marked shortening of the long axis

immune system
increased susceptibility to induced colitis ( J:67934 )
• development of intestinal inflammation occurs 3-5 days earlier when challenged with dextran sulfate than in controls
• more severe weight loss (28% vs 9% in controls)
• mortality also more rapid
• lesions more persistent into recovery period
• pathological changes most obvious in the distal large intestine including a marked shortening of the long axis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory