All Phenotypes Ephb1<tm1Cmn> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ephb1^tm1Cmn
targeted mutation 1, Carol A Mason
MGI:2677305

Summary

11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ephb1^tm1Cmn/Ephb1^tm1Cmn	involves: 129S1/Sv * 129X1/SvJ	MGI:5306419
hm2	Ephb1^tm1Cmn/Ephb1^tm1Cmn	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:2677319
ht3	Ephb1^tm1Cmn/Ephb1⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:5306418
ht4	Ephb1^tm1Cmn/Ephb1^tm2Cmn	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:2677322
cx5	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm1Paw/Ephb2^tm1Paw Ephb3^tm1Kln/Ephb3^tm1Kln	involves: 129/Sv * CD-1	MGI:2677321
cx6	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm1Paw/Ephb2⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:5306604
cx7	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm1Paw/Ephb2^tm1Paw	involves: 129S1/Sv * 129X1/SvJ	MGI:5306605
cx8	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm2Paw/Ephb2⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:5306606
cx9	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm2Paw/Ephb2^tm2Paw	involves: 129S1/Sv * 129X1/SvJ	MGI:5306607
cx10	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm1Paw/Ephb2^tm1Paw	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3851502
cx11	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm1Paw/Ephb2^tm1Paw Ephb3^tm1Kln/Ephb3^tm1Kln	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3851503

Allelic Composition	Ephb1^tm1Cmn/Ephb1^tm1Cmn
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1^tm1Cmn mutation (1 available); any Ephb1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal hippocampal mossy fiber innervation pattern ( J:267455 )

• longer mossy fiber axons penetrate the CA3 pyramidal cell layers

abnormal axon morphology ( J:176056 )

• most mice exhibit ventral-temporal (VT) retinal ganglion cell axon mapping defects compared with control mice

Allelic Composition	Ephb1^tm1Cmn/Ephb1^tm1Cmn
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1^tm1Cmn mutation (1 available); any Ephb1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon pruning ( J:150550 )

• mossy fiber pruning is defective

abnormal optic tract morphology ( J:85573 )

• marked reduction of the ipsilateral optic tract, by 43%, both at E17.5 and at birth

• axons from the ventrotemporal retina tend to cross the midline

• no obvious guidance errors in the optic nerve or tract other than ipsilateral reduction

abnormal axon morphology ( J:150550 )

• infra-pyramidal bundle (IPB) axons are longer than in wild-type mice

vision/eye

vision/eye phenotype ( J:85573 )

N	• no intraretinal axon guidance errors observed in E17.5 embryos

cellular

abnormal axon pruning ( J:150550 )

• mossy fiber pruning is defective

Allelic Composition	Ephb1^tm1Cmn/Ephb1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1^tm1Cmn mutation (1 available); any Ephb1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon morphology ( J:176056 )

• some mice exhibit ventral-temporal (VT) retinal ganglion cell axon mapping defects compared with control mice

Allelic Composition	Ephb1^tm1Cmn/Ephb1^tm2Cmn
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1^tm1Cmn mutation (1 available); any Ephb1 mutation (44 available)
Ephb1^tm2Cmn mutation (0 available); any Ephb1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye morphology ( J:85573 )

• express beta-gal in cells normally expressing Ephb1

abnormal optic nerve innervation ( J:85573 )

• embryos demonstrate misprojection of axons contralaterally

nervous system

abnormal optic nerve innervation ( J:85573 )

• embryos demonstrate misprojection of axons contralaterally

Allelic Composition	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm1Paw/Ephb2^tm1Paw Ephb3^tm1Kln/Ephb3^tm1Kln
Genetic Background	involves: 129/Sv * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1^tm1Cmn mutation (1 available); any Ephb1 mutation (44 available)
Ephb2^tm1Paw mutation (1 available); any Ephb2 mutation (68 available)
Ephb3^tm1Kln mutation (1 available); any Ephb3 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye morphology ( J:85573 )

nervous system

abnormal optic tract morphology ( J:85573 )

• axons from ventrotemporal retina tend to cross the midline

Allelic Composition	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm1Paw/Ephb2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon morphology ( J:176056 )

• most mice exhibit dorsal retinal ganglion cell axon mapping defects compared with control mice

Allelic Composition	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm1Paw/Ephb2^tm1Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon morphology ( J:176056 )

• most mice exhibit dorsal retinal ganglion cell axon mapping defects compared with control mice

Allelic Composition	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm2Paw/Ephb2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1^tm1Cmn mutation (1 available); any Ephb1 mutation (44 available)
Ephb2^tm2Paw mutation (0 available); any Ephb2 mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon morphology ( J:176056 )

• most mice exhibit dorsal retinal ganglion cell axon mapping defects compared with control mice

Allelic Composition	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm2Paw/Ephb2^tm2Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon morphology ( J:176056 )

• most mice exhibit dorsal retinal ganglion cell axon mapping defects compared with control mice

Allelic Composition	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm1Paw/Ephb2^tm1Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon pruning ( J:150550 )

• mossy fiber pruning is defective

abnormal axon morphology ( J:150550 )

• infra-pyramidal bundle (IPB) axons are longer than in wild-type mice

cellular

abnormal axon pruning ( J:150550 )

• mossy fiber pruning is defective

Allelic Composition	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm1Paw/Ephb2^tm1Paw Ephb3^tm1Kln/Ephb3^tm1Kln
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon pruning ( J:150550 )

• mossy fiber pruning is defective

abnormal axon morphology ( J:150550 )

• infra-pyramidal bundle (IPB) axons are longer than in wild-type mice

cellular

abnormal axon pruning ( J:150550 )

• mossy fiber pruning is defective

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 07/29/2025 MGI 6.24