All Phenotypes Ephb1<tm1Cmn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ephb1^tm1Cmn
targeted mutation 1, Carol A Mason
MGI:2677305

Summary

11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ephb1^tm1Cmn/Ephb1^tm1Cmn	involves: 129S1/Sv * 129X1/SvJ	MGI:5306419
hm2	Ephb1^tm1Cmn/Ephb1^tm1Cmn	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:2677319
ht3	Ephb1^tm1Cmn/Ephb1⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:5306418
ht4	Ephb1^tm1Cmn/Ephb1^tm2Cmn	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:2677322
cx5	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm1Paw/Ephb2^tm1Paw Ephb3^tm1Kln/Ephb3^tm1Kln	involves: 129/Sv * CD-1	MGI:2677321
cx6	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm1Paw/Ephb2⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:5306604
cx7	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm1Paw/Ephb2^tm1Paw	involves: 129S1/Sv * 129X1/SvJ	MGI:5306605
cx8	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm2Paw/Ephb2⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:5306606
cx9	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm2Paw/Ephb2^tm2Paw	involves: 129S1/Sv * 129X1/SvJ	MGI:5306607
cx10	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm1Paw/Ephb2^tm1Paw	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3851502
cx11	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm1Paw/Ephb2^tm1Paw Ephb3^tm1Kln/Ephb3^tm1Kln	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3851503

Allelic Composition	Ephb1^tm1Cmn/Ephb1^tm1Cmn
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1^tm1Cmn mutation (1 available); any Ephb1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal hippocampal mossy fiber morphology ( J:267455 )

• longer mossy fiber axons penetrate the CA3 pyramidal cell layers

abnormal axon morphology ( J:176056 )

• most mice exhibit ventral-temporal (VT) retinal ganglion cell axon mapping defects compared with control mice

Allelic Composition	Ephb1^tm1Cmn/Ephb1^tm1Cmn
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1^tm1Cmn mutation (1 available); any Ephb1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon pruning ( J:150550 )

• mossy fiber pruning is defective

abnormal optic tract morphology ( J:85573 )

• marked reduction of the ipsilateral optic tract, by 43%, both at E17.5 and at birth

• axons from the ventrotemporal retina tend to cross the midline

• no obvious guidance errors in the optic nerve or tract other than ipsilateral reduction

abnormal axon morphology ( J:150550 )

• infra-pyramidal bundle (IPB) axons are longer than in wild-type mice

vision/eye

vision/eye phenotype ( J:85573 )

N	• no intraretinal axon guidance errors observed in E17.5 embryos

cellular

abnormal axon pruning ( J:150550 )

• mossy fiber pruning is defective

Allelic Composition	Ephb1^tm1Cmn/Ephb1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1^tm1Cmn mutation (1 available); any Ephb1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon morphology ( J:176056 )

• some mice exhibit ventral-temporal (VT) retinal ganglion cell axon mapping defects compared with control mice

Allelic Composition	Ephb1^tm1Cmn/Ephb1^tm2Cmn
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1^tm1Cmn mutation (1 available); any Ephb1 mutation (44 available)
Ephb1^tm2Cmn mutation (0 available); any Ephb1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye morphology ( J:85573 )

• express beta-gal in cells normally expressing Ephb1

abnormal optic nerve innervation ( J:85573 )

• embryos demonstrate misprojection of axons contralaterally

nervous system

abnormal optic nerve innervation ( J:85573 )

• embryos demonstrate misprojection of axons contralaterally

Allelic Composition	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm1Paw/Ephb2^tm1Paw Ephb3^tm1Kln/Ephb3^tm1Kln
Genetic Background	involves: 129/Sv * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1^tm1Cmn mutation (1 available); any Ephb1 mutation (44 available)
Ephb2^tm1Paw mutation (1 available); any Ephb2 mutation (68 available)
Ephb3^tm1Kln mutation (1 available); any Ephb3 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye morphology ( J:85573 )

nervous system

abnormal optic tract morphology ( J:85573 )

• axons from ventrotemporal retina tend to cross the midline

Allelic Composition	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm1Paw/Ephb2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon morphology ( J:176056 )

• most mice exhibit dorsal retinal ganglion cell axon mapping defects compared with control mice

Allelic Composition	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm1Paw/Ephb2^tm1Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon morphology ( J:176056 )

• most mice exhibit dorsal retinal ganglion cell axon mapping defects compared with control mice

Allelic Composition	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm2Paw/Ephb2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1^tm1Cmn mutation (1 available); any Ephb1 mutation (44 available)
Ephb2^tm2Paw mutation (0 available); any Ephb2 mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon morphology ( J:176056 )

• most mice exhibit dorsal retinal ganglion cell axon mapping defects compared with control mice

Allelic Composition	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm2Paw/Ephb2^tm2Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon morphology ( J:176056 )

• most mice exhibit dorsal retinal ganglion cell axon mapping defects compared with control mice

Allelic Composition	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm1Paw/Ephb2^tm1Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon pruning ( J:150550 )

• mossy fiber pruning is defective

abnormal axon morphology ( J:150550 )

• infra-pyramidal bundle (IPB) axons are longer than in wild-type mice

cellular

abnormal axon pruning ( J:150550 )

• mossy fiber pruning is defective

Allelic Composition	Ephb1^tm1Cmn/Ephb1^tm1Cmn Ephb2^tm1Paw/Ephb2^tm1Paw Ephb3^tm1Kln/Ephb3^tm1Kln
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon pruning ( J:150550 )

• mossy fiber pruning is defective

abnormal axon morphology ( J:150550 )

• infra-pyramidal bundle (IPB) axons are longer than in wild-type mice

cellular

abnormal axon pruning ( J:150550 )

• mossy fiber pruning is defective

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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