Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnj9tm1Kwn mutation
(1 available);
any
Kcnj9 mutation
(31 available)
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nervous system
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• resting membrane potentials of locus ceruleus neurons in brain slices are depolarized by 15-20 mV relative to neurons from wild-type mice
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behavior/neurological
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N |
• mice are fertile and of normal size, exhibit normal coordination and show no abnormal feeding behavior, grooming, or responses to visual or auditory cues
• no observed propensity for spontaneous and lethal seizures
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnj6tm1Stf mutation
(0 available);
any
Kcnj6 mutation
(26 available)
Kcnj9tm1Kwn mutation
(1 available);
any
Kcnj9 mutation
(31 available)
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mortality/aging
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• between 2 and 8 months due to spontaneous seizures
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behavior/neurological
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• spontaneous lethal seizures between 2 and 8 months of age
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nervous system
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• spontaneous lethal seizures between 2 and 8 months of age
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• resting membrane potentials of locus ceruleus neurons in brain slices are depolarized by 15-20 mV realative to neurons from wild-type mice
• opioid ([Met]5 enkephalin)-induced hyperpolarization and whole-cell current is reduced by 80% in locus ceruleus neurons
• the small opioid-sensitive current that is observed in locus ceruleus neurons is eliminated with the nonselective potassium channel blockers barium and cesium
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Analysis Tools