Phenotypes associated with this allele

• Allele Symbol: Syt7^tm1Nan
• Allele Name: targeted mutation 1, Norma W Andrews
• Allele ID: MGI:2676220
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Syt7^tm1Nan/Syt7^tm1Nan	involves: 129S1/Sv * C57BL/6	MGI:2676272

Genotype
MGI:2676272

hm1

• Allelic Composition: Syt7^tm1Nan/Syt7^tm1Nan
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Inflammation, injury and fibrosis in skin and skeletal muscle of Syt7^tm1Nan/Syt7^tm1Nan mice

cellular

abnormal cell physiology ( J:85201 )

• embryo fibroblasts are resistant to invasion by Trypanosoma cruzi

• failure of exocytosis and wound resealing in embryo fibroblasts

immune system

increased susceptibility to autoimmune disorder ( J:85201 )

• similarities to human autoimmune polymyositis/dermatositis

increased anti-nuclear antigen antibody level ( J:85201 )

• antinuclear antibody response in serum by 19 weeks

increased inflammatory response ( J:85201 )

myositis ( J:85201 )

• extensive endomysial cellular infiltration at week 4

• week 8, scattered foci of inflammation

• invasion of degenerating muscle fibers by macrophages and eosinophiles

• inflammatory cells less abundant as mice age but fibrosis detectable until week 44

muscle

myositis ( J:85201 )

• extensive endomysial cellular infiltration at week 4

• week 8, scattered foci of inflammation

• invasion of degenerating muscle fibers by macrophages and eosinophiles

• inflammatory cells less abundant as mice age but fibrosis detectable until week 44

abnormal skeletal muscle morphology ( J:85201 )

• extensive endomysial cellular infiltration at 4 weeks

• by 8 weeks, mast cells and bundles of collagen fibers found in endomysial space

• fiber degeneration

skeletal muscle interstitial fibrosis ( J:85201 )

• enhanced accumulation of connective tissue elements seen histologically in the skin and skeletal muscle (fibrosis)

reproductive system

abnormal fertility/fecundity ( J:85201 )

• reproductive capacity declines faster with age (litters of 3 at 6 months as opposed to 7 for wild-type mice)

• normal fertility otherwise

behavior/neurological

decreased grip strength ( J:85201 )

• decreased forelimb grip strength after 19 weeks

integument

skin fibrosis ( J:85201 )

• enhanced accumulation of connective tissue elements seen histologically in the skin and skeletal muscle (fibrosis)

• increased collagen deposition not seen in other tissues