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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Badtm1Sjk
targeted mutation 1, Stanley J Korsmeyer
MGI:2675966
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Badtm1Sjk/Badtm1Sjk B6.129X1-Badtm1Sjk MGI:3796613
hm2
 		Badtm1Sjk/Badtm1Sjk either: 129X1/SvJ or (involves: 129X1/SvJ * C57BL/6) MGI:2675997
hm3
 		Badtm1Sjk/Badtm1Sjk involves: 129X1/SvJ MGI:3785249
cx4
 		Badtm1Sjk/Badtm1Sjk
Tg(Ins2-Mirc13)E4Biat/0 		involves: 129X1/SvJ * C57BL/6N MGI:6829608


Genotype
MGI:3796613
hm1
Allelic
Composition		 Badtm1Sjk/Badtm1Sjk
Genetic
Background		 B6.129X1-Badtm1Sjk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Badtm1Sjk mutation (0 available); any Bad mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal hippocampus morphology ( J:111236 )
• 2 days after neonatal hypoxia-ischemia (HI) injury, ispsilateral hippocampal area loss (10.3%) is half of that seen in wild-type mice (21%) after HI
gliosis ( J:111236 )
• reactive gliosis is significantly decreased in hippocampi of mutants 2 days after neonatal HI compared to wild-type




Genotype
MGI:2675997
hm2
Allelic
Composition		 Badtm1Sjk/Badtm1Sjk
Genetic
Background		 either: 129X1/SvJ or (involves: 129X1/SvJ * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Badtm1Sjk mutation (0 available); any Bad mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:84987 )
• increased death rate due to malignancies over a 2 year period
• 80% survive past 18 months as compared to 100% for wild-type mice

neoplasm
increased tumor incidence ( J:84987 )
• other tumor types (non lymphomas) occur in smaller numbers
increased lymphoma incidence ( J:84987 )
• about 20% develop diffuse large cell type lymphomas involving spleen and lymph nodes
increased B cell derived lymphoma incidence ( J:84987 )
• usually germinal center B cell lymphomas

cellular
multinucleated giant male germ cells ( J:84987 )
• prominent multinucleated giant cells in seminiferous tubules
increased cellular sensitivity to gamma-irradiation ( J:84987 )
• after irradiation at 4 weeks of age early T-cell lymphomas and later B-cell lymphomas
abnormal apoptosis ( J:84987 )
• epithelial cells and embryonic fibroblasts with increased resistance to apoptosis from various stimuli

endocrine/exocrine glands
abnormal testis morphology ( J:84987 )
• males were fertile despite abnormalities

immune system
abnormal B cell physiology ( J:84987 )
• normal IgM production but reduced IgG after lipopolysaccharide stimulation
abnormal T cell physiology ( J:84987 )
• a modest delay in the course of death among thymocytes exposed to gamma radiation

reproductive system
multinucleated giant male germ cells ( J:84987 )
• prominent multinucleated giant cells in seminiferous tubules
abnormal testis morphology ( J:84987 )
• males were fertile despite abnormalities

hematopoietic system
abnormal B cell physiology ( J:84987 )
• normal IgM production but reduced IgG after lipopolysaccharide stimulation
abnormal T cell physiology ( J:84987 )
• a modest delay in the course of death among thymocytes exposed to gamma radiation




Genotype
MGI:3785249
hm3
Allelic
Composition		 Badtm1Sjk/Badtm1Sjk
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Badtm1Sjk mutation (0 available); any Bad mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased pancreatic islet number ( J:133563 )
• higher number of islets on a high fat diet
abnormal pancreatic beta cell physiology ( J:133563 )
• reduced sensitivity to apoptosis
decreased insulin secretion ( J:133563 )
• isolated islet cells require more glucose to induce insulin release equivalent to that of controls

homeostasis/metabolism
decreased insulin secretion ( J:133563 )
• isolated islet cells require more glucose to induce insulin release equivalent to that of controls
abnormal circulating glucose level ( J:133563 )
• resistance to hyperglycemia induced by a high fat diet
increased circulating insulin level ( J:133563 )
• elevated blood insulin levels on a high fat diet

immune system
immune system phenotype ( J:132819 )
N
• no abnormalities are detected in T cell numbers after HSV-1 infection




Genotype
MGI:6829608
cx4
Allelic
Composition		 Badtm1Sjk/Badtm1Sjk
Tg(Ins2-Mirc13)E4Biat/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Badtm1Sjk mutation (0 available); any Bad mutation (25 available)
Tg(Ins2-Mirc13)E4Biat mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
hyperglycemia ( J:314874 )
• after a 4 h fast, mice exhibit increased blood glucose levels as in mice with the transgene alone




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory