Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syn3tm1Pggd mutation
(2 available);
any
Syn3 mutation
(35 available)
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behavior/neurological
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• in the social transmission of food preference task, mutants show an absence of preference for the cued food over the novel food after one hour after social interaction with the demonstrator cagemate
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• in the social dominance tube test, adults show more submissive behavior than controls
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• in the social novelty test, young mutants do not discriminate between familiar and novel mice compared to controls that spend more time exploring the novel mouse than a familiar mouse indicating altered social novelty preference
• in the resident-intruder test, mutants show reduced social interaction with the intruder mice after 1-2 months of social isolation
• however, mutants exhibit normal anxiety related behaviors
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taste/olfaction
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syn3tm1Pggd mutation
(2 available);
any
Syn3 mutation
(35 available)
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nervous system
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• observed in hippocampal neurons in culture
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• a slightly larger amplitude was noted
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• a reduction in amplitude was noted
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• reduced transmission noted after a 5 second stimulation in homozygotes
• time constants for depression range is increased two fold
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cellular
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• observed in hippocampal neurons in culture
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behavior/neurological
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• opening of the home cage of adult mutants induces generalized tonic-clonic seizures that correlate with high amplitude and high frequency generalized synchronized activity followed by post-ictal depression in the theta frequency rage (3-6 Hz)
• seizures commence within seconds of cage opening and include vocalization, freezing, tail stiffing, back arching, bilateral limb movements, and loss of posture, followed by stereotypical grooming behavior
• the symptomatic seizure state is characterized by resistance to the epileptiform-promoting effects of 4-aminopyridine, by hypersensitivity to blockage of GABA(A) receptors and by the emergence of unresponsiveness to NMDA receptor antagonism
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• opening of the home cage of adult mutants induces generalized tonic-clonic seizures
• however, mice exhibit spontaneous seizures only vary rarely
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nervous system
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• opening of the home cage of adult mutants induces generalized tonic-clonic seizures that correlate with high amplitude and high frequency generalized synchronized activity followed by post-ictal depression in the theta frequency rage (3-6 Hz)
• seizures commence within seconds of cage opening and include vocalization, freezing, tail stiffing, back arching, bilateral limb movements, and loss of posture, followed by stereotypical grooming behavior
• the symptomatic seizure state is characterized by resistance to the epileptiform-promoting effects of 4-aminopyridine, by hypersensitivity to blockage of GABA(A) receptors and by the emergence of unresponsiveness to NMDA receptor antagonism
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• opening of the home cage of adult mutants induces generalized tonic-clonic seizures
• however, mice exhibit spontaneous seizures only vary rarely
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• EEG indicates an abrupt transition during early adulthood from a seizure-free presymptomatic latent state to a consistent symptomatic state of sensory-induced seizures
• EEG indicates that during the latent period, larger field responses are elicited in slices from mutants than in controls
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