Phenotypes associated with this allele

• Allele Symbol: Noxo1^hslt
• Allele Name: head slant
• Allele ID: MGI:2675672
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Noxo1^hslt/Noxo1^hslt	SJL.Cg Thy1^a-Noxo1^hslt/J	MGI:2678327

Genotype
MGI:2678327

hm1

• Allelic Composition: Noxo1^hslt/Noxo1^hslt
• Genetic Background: SJL.Cg Thy1^a-Noxo1^hslt/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Vestibular defect causing tilting of the head in Noxo1^hslt/Noxo1^hslt mice

behavior/neurological

impaired righting response ( J:106332 )

• impairment noted as early as 4 days after birth

abnormal placing response ( J:106332 )

• abnormal reaching response compared to controls

impaired balance ( J:106332 )

• mice could not orient with respect to gravity

head tilt ( J:86035 , J:106332 )

• mice walk with their heads tilted to one side (J:86035)

circling ( J:86035 )

• mice exhibit some circling behavior

hearing/vestibular/ear

absent otoliths ( J:86035 , J:106332 )

• microscopic examination of the inner ear revealed absence of otoconia in the saccule and utricle (J:86035)

• acoustic brainstem response (ABR) is normal, demonstrating that the mice are not deaf (J:86035)

• all other structures of the inner ear appeared intact (J:106332)

• coral-like conglomerates appear upon the hair cells and may be an unmineralized precursor to the otoliths (J:106332)