All Phenotypes Cdk2<tm1Sgo> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cdk2^tm1Sgo
targeted mutation 1, Sagrario Ortega
MGI:2675585

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdk2^tm1Sgo/Cdk2^tm1Sgo	involves: 129/Sv * CD-1	MGI:2675622
cn2	Cdk2^tm1Sgo/Cdk2^tm1Sgo Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd}	involves: 129S1/Sv * 129X1/SvJ	MGI:4844195
cx3	Cdk2^tm1Sgo/Cdk2^tm1Sgo Cdk4^tm2.1Bbd/Cdk4^tm2.1Bbd	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL	MGI:3759575
cx4	Cdk2^tm1Sgo/Cdk2⁺ Cdk4^tm2.1Bbd/Cdk4⁺	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL	MGI:3759576
cx5	Cdk2^tm1Sgo/Cdk2^tm1Sgo Cdk4^tm1Bbd/Cdk4^tm1Bbd Cdk6^tm1Bbd/Cdk6^tm1Bbd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3723204
cx6	Cdk2^tm1Sgo/Cdk2^tm1Sgo Cdk6^tm1Bbd/Cdk6^tm1Bbd	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3054096

Allelic Composition	Cdk2^tm1Sgo/Cdk2^tm1Sgo
Genetic Background	involves: 129/Sv * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk2^tm1Sgo mutation (1 available); any Cdk2 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal female reproductive system morphology ( J:85230 )

• oviducts and uterus normal

absent corpus luteum ( J:85230 )

absent ovarian follicles ( J:85230 )

ovary atrophy ( J:85230 )

• by day 120 ovaries are atrophic (15-20% normal size)

• frequently find epithelium lined cysts replacing ovarian tissue

abnormal gametogenesis ( J:85230 )

• failure of both oogenesis and spermatogenesis

abnormal oocyte morphology ( J:85230 )

• ovaries normal through E17.5 when oocytes reach pachytene stage of meiosis

• by day 1 after birth when oocytes should be in late diplotene stage, few oocytes are left and apoptosis is occurring

abnormal meiosis ( J:85230 )

• failure of chromosome pairing

• meiosis fails to proceed past the pachytene stage of prophase I

abnormal spermiogenesis ( J:85230 )

• testes normal to day 15 when germ cells are tetraploid primary sperm cells

• by day 20, an absence of expected round spermatids

• apoptosis of spermatocytes occuring at day 20

abnormal male reproductive system morphology ( J:85230 )

abnormal seminiferous tubule morphology ( J:85230 )

• normal proliferation of spermatogonia through day 30 when seminiferous tubules are almost completely depleted of germ cells

testicular atrophy ( J:85230 )

• by day 120, testes are atrophic (20% normal size)

• normal levels of spermatogonia, Sertoli and Leydig cells

• few primary spermatocytes

• no post meiotic cells

abnormal fertility/fecundity ( J:85230 )

infertility ( J:85230 )

• both sexes were totally sterile

endocrine/exocrine glands

absent corpus luteum ( J:85230 )

absent ovarian follicles ( J:85230 )

ovary atrophy ( J:85230 )

• by day 120 ovaries are atrophic (15-20% normal size)

• frequently find epithelium lined cysts replacing ovarian tissue

abnormal seminiferous tubule morphology ( J:85230 )

• normal proliferation of spermatogonia through day 30 when seminiferous tubules are almost completely depleted of germ cells

testicular atrophy ( J:85230 )

• by day 120, testes are atrophic (20% normal size)

• normal levels of spermatogonia, Sertoli and Leydig cells

• few primary spermatocytes

• no post meiotic cells

cellular

abnormal oocyte morphology ( J:85230 )

• ovaries normal through E17.5 when oocytes reach pachytene stage of meiosis

• by day 1 after birth when oocytes should be in late diplotene stage, few oocytes are left and apoptosis is occurring

abnormal meiosis ( J:85230 )

• failure of chromosome pairing

• meiosis fails to proceed past the pachytene stage of prophase I

Allelic Composition	Cdk2^tm1Sgo/Cdk2^tm1Sgo Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk2^tm1Sgo mutation (1 available); any Cdk2 mutation (17 available)
Kras^tm1Bbd mutation (2 available); any Kras mutation (76 available)
Polr2a^{tm1(cre/ERT2)Bbd} mutation (3 available); any Polr2a mutation (92 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:161780 )

• mice treated tamoxifen at weaning exhibit an increase in lifespan of 8 weeks (42 weeks) compared with similarly treated Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} littermates (34 weeks)

neoplasm

decreased tumor incidence ( J:161780 )

• tamoxifen-treated mice exhibit reduced tumor burden compared with similarly treated Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} mice

Allelic Composition	Cdk2^tm1Sgo/Cdk2^tm1Sgo Cdk4^tm2.1Bbd/Cdk4^tm2.1Bbd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk2^tm1Sgo mutation (1 available); any Cdk2 mutation (17 available)
Cdk4^tm2.1Bbd mutation (1 available); any Cdk4 mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:125217 )

• although mice move and ingest milk at birth, they die within 24 hours due to cardiac failure

cardiovascular system

increased myocardial fiber size ( J:125217 )

• in some cases cardiomyocytes are hypertrophic and are partially disorganized by prominent capillaries

thin ventricular wall ( J:125217 )

• thin ventricular walls are associated with a one-third decrease in the number of proliferating cardiomyocytes

abnormal fetal cardiomyocyte proliferation ( J:125217 )

• thin ventricular walls are associated with a one-third decrease in the number of proliferating cardiomyocytes

congestive heart failure ( J:125217 )

• mice die within 24 hours of birth due to cardiac failure

liver/biliary system

liver hypoplasia ( J:125217 )

• fetal livers contain 60% of the cells found in wild-type livers

• however, this reduction is proportional to the reduction in overall size of embryos

• the number of hematopoietic cells in the fetal liver is reduced compared to in wild-type mice

abnormal liver physiology ( J:125217 )

• mice suffer from congestive livers

hematopoietic system

abnormal definitive hematopoiesis ( J:125217 )

• the number of hematopoietic cells in the fetal liver is reduced compared to in wild-type mice

• however, the number of granulocyte-macrophage progenitors, common myeloid progenitors and megakaryocyte-erythroid progenitor cells are normal

decreased erythrocyte cell number ( J:125217 )

• at E17.5, mice have a small decrease in red blood cell (RBC) number (1.27x10⁶+/-0.14 RBC per mm³ compared to 1.45x10⁶+/-0.11 RBC per mm³ in wild-type mice)

• however, this decrease does not affect viability

cellular

abnormal fetal cardiomyocyte proliferation ( J:125217 )

• thin ventricular walls are associated with a one-third decrease in the number of proliferating cardiomyocytes

abnormal cell cycle ( J:125217 )

• primary mouse embryonic fibroblast cells are delayed in the percent of cells entering into S phase but eventually equalize with wild-type cells

decreased fibroblast proliferation ( J:125217 )

• proliferation of mouse embryonic fibroblast (MEF) cells is decreased relative to wild-type MEFs

growth/size/body

decreased body weight ( J:125217 )

• at birth mice weigh 25% to 40% less than wild-type mice

muscle

increased myocardial fiber size ( J:125217 )

• in some cases cardiomyocytes are hypertrophic and are partially disorganized by prominent capillaries

abnormal fetal cardiomyocyte proliferation ( J:125217 )

• thin ventricular walls are associated with a one-third decrease in the number of proliferating cardiomyocytes

Allelic Composition	Cdk2^tm1Sgo/Cdk2⁺ Cdk4^tm2.1Bbd/Cdk4⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryo development ( J:125217 )

• 60% of mice do not complete embryonic development

Allelic Composition	Cdk2^tm1Sgo/Cdk2^tm1Sgo Cdk4^tm1Bbd/Cdk4^tm1Bbd Cdk6^tm1Bbd/Cdk6^tm1Bbd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk2^tm1Sgo mutation (1 available); any Cdk2 mutation (17 available)
Cdk4^tm1Bbd mutation (1 available); any Cdk4 mutation (57 available)
Cdk6^tm1Bbd mutation (1 available); any Cdk6 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:124678 )

• mice begin to die around E13.5 and all are dying by E15.5

embryonic lethality during organogenesis, incomplete penetrance ( J:124678 )

• mice begin to die around E13.5 and all are dying by E15.5

growth/size/body

decreased embryo size ( J:124678 )

• between E12.5 and E13.5, embryos are 25% to 40% smaller than wild-type mice

cardiovascular system

decreased myocardial fiber number ( J:124678 )

• the number of proliferating cardiomyocytes is decreased resulting in thin ventricular walls

thin ventricular wall ( J:124678 )

• ventricular walls are thinner than in wild-type mice due to a decrease in the number of proliferating cardiomyocytes

cellular

decreased cell proliferation ( J:124678 )

• proliferation of mouse embryonic fibroblast cells is partially compromised

• exiting quiescence following serum treatment is delayed

liver/biliary system

liver hypoplasia ( J:124678 )

• between E12.5 and E13.5, livers exhibit a three-fold reduction in cellularity that is not accounted for by the decrease in embryo size

hematopoietic system

abnormal common myeloid progenitor cell morphology ( J:124678 )

• common myeloid progenitor cells are reduced 8-fold in number

muscle

decreased myocardial fiber number ( J:124678 )

• the number of proliferating cardiomyocytes is decreased resulting in thin ventricular walls

embryo

decreased embryo size ( J:124678 )

• between E12.5 and E13.5, embryos are 25% to 40% smaller than wild-type mice

Allelic Composition	Cdk2^tm1Sgo/Cdk2^tm1Sgo Cdk6^tm1Bbd/Cdk6^tm1Bbd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk2^tm1Sgo mutation (1 available); any Cdk2 mutation (17 available)
Cdk6^tm1Bbd mutation (1 available); any Cdk6 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal gametogenesis ( J:92529 )

abnormal oogenesis ( J:92529 )

• marked defects in oogenesis seen

abnormal spermatogenesis ( J:92529 )

• marked defects in spermatogenesis seen

infertility ( J:92529 )

• double homozygotes are sterile

cellular

abnormal oogenesis ( J:92529 )

• marked defects in oogenesis seen

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23