Phenotypes associated with this allele

• Allele Symbol: Ptch1^tm1.1Bjw
• Allele Name: targeted mutation 1.1, Brandon J Wainwright
• Allele ID: MGI:2675358
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptch1^tm1.1Bjw/Ptch1^tm1.1Bjw	involves: 129T2/SvEms * C57BL/6J	MGI:2675360

Genotype
MGI:2675360

hm1

• Allelic Composition: Ptch1^tm1.1Bjw/Ptch1^tm1.1Bjw
• Genetic Background: involves: 129T2/SvEms * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality ( J:85040 )

craniofacial

abnormal craniofacial morphology ( J:85040 )

• craniofacial defects due to open neural tube

embryo

embryonic growth arrest ( J:85040 )

• severely affected embryos are arrested in development around E8.5

open neural tube ( J:85040 )

• failure of neural tube closure to varying degrees

nervous system

open neural tube ( J:85040 )

• failure of neural tube closure to varying degrees

abnormal telencephalon development ( J:85040 )

• lack of tissue overlying the telencephalic vesicle

absent forebrain ( J:85040 )

• some embryos lack forebrain structures