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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd59atm1Song
targeted mutation 1, Wen-Chao Song
MGI:2675293
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd59atm1Song/Cd59atm1Song involves: 129S6/SvEvTac MGI:2675294
cx2
 		Cd59atm1Song/Cd59atm1Song
Cd55tm1Song/Cd55tm1Song 		involves: 129S6/SvEvTac * C57BL/6 MGI:3581707


Genotype
MGI:2675294
hm1
Allelic
Composition		 Cd59atm1Song/Cd59atm1Song
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd59atm1Song mutation (2 available); any Cd59a mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal complement pathway ( J:76578 )
• erythrocytes are more susceptible to autologous and heterologous MAC lysis under conditions of induced complement activation by antibodies or cobra venom factor (CVF)
• however, erythrocytes have a normal lifespan in vivo and mice do not develop spontaneous hemolytic anemia




Genotype
MGI:3581707
cx2
Allelic
Composition		 Cd59atm1Song/Cd59atm1Song
Cd55tm1Song/Cd55tm1Song
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd55tm1Song mutation (2 available); any Cd55 mutation (39 available)
Cd59atm1Song mutation (2 available); any Cd59a mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal complement pathway ( J:76578 )
• in vitro, double-mutant erythrocytes display a significantly increased sensitivity to antibody-induced autologous and heterologous complement lysis by membrane attack complex (MAC) relative to wild-type or single mutant erythrocytes

hematopoietic system
hematopoietic system phenotype ( J:76578 )
N
• despite enhanced sensitivity to antibody-induced complement lysis in vitro, double mutants develop no signs of hemolytic anemia and are resistant to spontaneous complement attack in vivo
• total peripheral erythrocyte counts, blood hemoglobin concentrations, and the average reticulocyte count remain unaffected; transfusion experiments confirm normal erythrocyte lifespans in vivo




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory