Phenotypes associated with this allele

• Allele Symbol: H2-Oa^tm1Lkar
• Allele Name: targeted mutation 1, Lars Karlsson
• Allele ID: MGI:2675254
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	H2-Oa^tm1Lkar/H2-Oa^tm1Lkar	involves: 129P2/OlaHsd	MGI:2675257

Genotype
MGI:2675257

hm1

• Allelic Composition: H2-Oa^tm1Lkar/H2-Oa^tm1Lkar
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:85084 )

N • cells have normal levels of class II expression and the density of H2-A^b-CLIP (class II-associated invariant chain peptides) at the cell surface is the same as in wild-type

increased IgG1 level ( J:85084 )

• older mutants exhibit elevated serum levels of IgG1

abnormal antigen presentation via MHC class II ( J:85084 )

• B cells have changed capacity to present protein antigens, showing better presentation by mutant B cells after overnight incubation with the antigen, hen egg lysozyme and sperm whale myoglobin, than wild-type cells

hematopoietic system

increased IgG1 level ( J:85084 )

• older mutants exhibit elevated serum levels of IgG1