Phenotypes associated with this allele

• Allele Symbol: Sigirr^tm1Lix
• Allele Name: targeted mutation 1, Xiaoxia Li
• Allele ID: MGI:2675236
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sigirr^tm1Lix/Sigirr^tm1Lix	involves: 129S6/SvEvTac * BALB/c	MGI:2675240

Genotype
MGI:2675240

hm1

• Allelic Composition: Sigirr^tm1Lix/Sigirr^tm1Lix
• Genetic Background: involves: 129S6/SvEvTac * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal splenocyte proliferation ( J:85151 )

• splenocytes show enhanced cell proliferation after lipopolysaccharide (LPS) or CpG treatments

abnormal chemokine secretion ( J:85151 )

• mutants show enhanced chemokine induction in the lung and colon, but not the liver, after IL-1 injection and for a longer time than in wild-type mice

increased inflammatory response ( J:85151 )

• mice show a more potent inflammatory response than wild-type controls when injected with TLR4 activator LPS

• primary kidney cells and splenocytes show enhanced activation in response to either IL-1 or Toll ligands

increased susceptibility to endotoxin shock ( J:85151 )

• mutants exhibit reduced survival after endotoxin (LPS) challenge, with only a 10% survival compared to 70% in wild-type mice

hematopoietic system

abnormal splenocyte proliferation ( J:85151 )

• splenocytes show enhanced cell proliferation after lipopolysaccharide (LPS) or CpG treatments

cellular

abnormal splenocyte proliferation ( J:85151 )

• splenocytes show enhanced cell proliferation after lipopolysaccharide (LPS) or CpG treatments