All Phenotypes Cacna1c<tm3Hfm> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cacna1c^tm3Hfm/Cacna1c^tm3Hfm Tg(Ins2-cre)25Mgn/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA	MGI:2674123
cn2	Cacna1c^tm3Hfm/Cacna1c^tm4Hfm A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:5291995

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased insulin secretion ( J:84919 )

• intraperitoneal glucose challenge in fed mice results in a slight reduction in plasma insulin levels and marked reduction of glucose-induced first-phase insulin secretion

• glucose-induced first phase (less than 5 min) insulin secretion in in situ pancreatic perfusions is inhibited by 78%

• glucose-induced insulin secretion in isolated islets is much lower than in control islets

increased circulating glucose level ( J:84919 )

• mutants exhibit a slight hyperglycemia under basal and fasted conditions

decreased circulating insulin level ( J:84919 )

• intraperitoneal glucose challenge in fed mice results in a slight reduction in plasma insulin levels and marked reduction of glucose-induced first-phase insulin secretion

impaired glucose tolerance ( J:84919 )

• intraperitoneal glucose challenge in fed mice shows impaired glucose tolerance

endocrine/exocrine glands

abnormal pancreatic beta cell physiology ( J:84919 )

• calcium currents are reduced in beta cells from mutant mice

• exocytosis in response to the initial depolarizations is reduced in single beta cells

decreased insulin secretion ( J:84919 )

• intraperitoneal glucose challenge in fed mice results in a slight reduction in plasma insulin levels and marked reduction of glucose-induced first-phase insulin secretion

• glucose-induced first phase (less than 5 min) insulin secretion in in situ pancreatic perfusions is inhibited by 78%

• glucose-induced insulin secretion in isolated islets is much lower than in control islets

Allelic Composition	Cacna1c^tm3Hfm/Cacna1c^tm4Hfm A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cf^{Tg(Myh6-cre/Esr1*)1Jmk} mutation (5 available); any A1cf mutation (39 available)
Cacna1c^tm3Hfm mutation (1 available); any Cacna1c mutation (141 available)
Cacna1c^tm4Hfm mutation (0 available); any Cacna1c mutation (141 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:175463 )

• mice die within 3 weeks of tamoxifen treatment

muscle

abnormal muscle electrophysiology ( J:175463 )

• vetricular cardiomyocytes from tamoxifen-treated mice exhibit reduced current-voltage relation of current compared with cells from control mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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