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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mdm2tm1.1Mep
targeted mutation 1.1, Mary Ellen Perry
MGI:2673928
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mdm2tm1.1Mep/Mdm2tm1.1Mep involves: 129S7/SvEvBrd * C57BL/6 MGI:3715444
ht2
 		Mdm2tm1Mep/Mdm2tm1.1Mep involves: 129S7/SvEvBrd * C57BL/6 * FVB MGI:3715446
ht3
 		Mdm2tm1Bay/Mdm2tm1.1Mep involves: 129S7/SvEvBrd * C57BL/6 * FVB MGI:3715441


Genotype
MGI:3715444
hm1
Allelic
Composition		 Mdm2tm1.1Mep/Mdm2tm1.1Mep
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1.1Mep mutation (1 available); any Mdm2 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:81065 )
• no homozygous offspring are produced




Genotype
MGI:3715446
ht2
Allelic
Composition		 Mdm2tm1Mep/Mdm2tm1.1Mep
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1.1Mep mutation (1 available); any Mdm2 mutation (54 available)
Mdm2tm1Mep mutation (1 available); any Mdm2 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:81065 )
• at 5 weeks of age, a 15-20% reduction in body weight is observed relative to wild-type mice

hematopoietic system
decreased thymus weight ( J:81065 )
• thymus wet weight is significantly less than in wild-type
decreased spleen weight ( J:81065 )
• spleen wet weight is less than in wild-type

immune system
decreased thymus weight ( J:81065 )
• thymus wet weight is significantly less than in wild-type
decreased spleen weight ( J:81065 )
• spleen wet weight is less than in wild-type

liver/biliary system
decreased liver weight ( J:81065 )
• liver wet weight is significantly less than in wild-type

renal/urinary system
decreased kidney weight ( J:81065 )
• kidney wet weight is less than in wild-type

endocrine/exocrine glands
decreased thymus weight ( J:81065 )
• thymus wet weight is significantly less than in wild-type




Genotype
MGI:3715441
ht3
Allelic
Composition		 Mdm2tm1Bay/Mdm2tm1.1Mep
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1.1Mep mutation (1 available); any Mdm2 mutation (54 available)
Mdm2tm1Bay mutation (1 available); any Mdm2 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:81065 )
• no offspring heterozygous for the two mutant Mdm2 alleles are produced




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory