Phenotypes associated with this allele

• Allele Symbol: Kcnk5^{Gt(pGT1.8TM)1Gray}
• Allele Name: gene trap 1, Andrew T Gray
• Allele ID: MGI:2673542
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnk5^Gt(pGT1.8TM)1Gray/Kcnk5^Gt(pGT1.8TM)1Gray	B6.129P2-Kcnk5^Gt(pGT1.8TM)1Gray	MGI:3583009
hm2	Kcnk5^Gt(pGT1.8TM)1Gray/Kcnk5^Gt(pGT1.8TM)1Gray	involves: 129P2/OlaHsd * C57BL/6J	MGI:3583008

Genotype
MGI:3583009

hm1

• Allelic Composition: Kcnk5^{Gt(pGT1.8TM)1Gray}/Kcnk5^{Gt(pGT1.8TM)1Gray}
• Genetic Background: B6.129P2-Kcnk5^{Gt(pGT1.8TM)1Gray}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:90686 )

• Background Sensitivity: prenatal lethality becomes more pronounced when C57BL/6J is a more significant part of the genetic background

• survivors thrive and are fertile

growth/size/body

decreased body weight ( J:90686 )

renal/urinary system

increased urine chloride ion level ( J:90686 )

• slightly increased chloride excretion

increased urine sodium level ( J:90686 )

• slightly

abnormal renal filtration rate ( J:90686 )

• reduced inulin clearance

homeostasis/metabolism

increased urine chloride ion level ( J:90686 )

• slightly increased chloride excretion

increased urine sodium level ( J:90686 )

• slightly

Genotype
MGI:3583008

hm2

• Allelic Composition: Kcnk5^{Gt(pGT1.8TM)1Gray}/Kcnk5^{Gt(pGT1.8TM)1Gray}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

mortality/aging

prenatal lethality, incomplete penetrance ( J:85252 )

• Background Sensitivity: some prenatal lethality among females but not among males when C57BL/6J is less prominent in the genetic background