Phenotypes associated with this allele

• Allele Symbol: Rbp2^tm1Eli
• Allele Name: targeted mutation 1, Ellen Li
• Allele ID: MGI:2672086
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rbp2^tm1Eli/Rbp2^tm1Eli	B6.129-Rbp2^tm1Eli	MGI:2672088

Genotype
MGI:2672088

hm1

• Allelic Composition: Rbp2^tm1Eli/Rbp2^tm1Eli
• Genetic Background: B6.129-Rbp2^tm1Eli

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal vitamin absorption ( J:79282 )

• impaired saturable intestinal uptake of retinol

homeostasis/metabolism

abnormal vitamin absorption ( J:79282 )

• impaired saturable intestinal uptake of retinol

abnormal retinol level ( J:79282 )

• 40% reduction in hepatic retinol levels and normal serum retinol levels in mice fed a retinol-enriched diet

• when dietary retinol is limiting, females exhibit inadequate transport of retinol to the fetus resulting in increased neonatal mortality

cellular

maternal effect ( J:79282 )

• homozygous females bred to homozygous males and fed a vitamin A-deficient diet beginning on day 10 of pregnancy, show 100% mortality of pups within 24 hours and the E18 fetuses have 40% reduced levels of unesterified retinol in lungs

• heterozygous pups born to homozygous dams that were fed a vitamin A-deficient diet beginning on day 10 or pregnancy, exhibit increased neonatal mortality, appear cyanotic and less active at birth, have an enlarged right atrium engorged with blood, and exhibit hemorrhage and decreased air space in the lungs