Phenotypes associated with this allele

• Allele Symbol: Med31^l11Jus15
• Allele Name: lethal, Chr 11, Justice 15
• Allele ID: MGI:2671886
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Med31^l11Jus15/Med31^l11Jus15	involves: 129S5/SvEvBrd * C57BL/6J	MGI:4459854
hm2	Med31^l11Jus15/Med31^l11Jus15	involves: C57BL/6J	MGI:2673595

Genotype
MGI:4459854

hm1

• Allelic Composition: Med31^l11Jus15/Med31^l11Jus15
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:161417 )

• all mice die during late-gestation

skeleton

abnormal skeleton morphology ( J:161417 )

• at E17.5, most bones are smaller than in wild-type mice especially in the rib care but less in the skull

• however, skeletal patterning is normal

small cranium ( J:161417 )

small thoracic cage ( J:161417 )

abnormal cartilage development ( J:161417 )

• marker expression indicates delayed or reduced chondrogenesis compared with wild-type mice

decreased bone ossification ( J:161417 )

• digits exhibit reduced ossification, especially in the hind paw, compared to in wild-type mice

growth/size/body

embryonic growth retardation ( J:161417 )

• in 57% of mice at E9.5

decreased embryo size ( J:161417 )

• 57% of mice at E9.5

• all mice at E10.5

decreased fetal size ( J:161417 )

• mice that survive to E18.5

embryo

embryonic growth retardation ( J:161417 )

• in 57% of mice at E9.5

decreased embryo size ( J:161417 )

• 57% of mice at E9.5

• all mice at E10.5

spina bifida ( J:161417 )

• Background Sensitivity: in fewer mice than on a background without 129S5/SvEvBrd

cellular

decreased cell proliferation ( J:161417 )

• at E10.5, decreased cell proliferation is observed in the regions of the head, trunk, and forelimb compared to in wild-type mice

decreased fibroblast proliferation ( J:161417 )

• mouse embryonic fibroblasts exhibit reduced proliferation in culture compared with wild-type cells

homeostasis/metabolism

edema ( J:161417 )

• Background Sensitivity: in fewer mice than on a background without 129S5/SvEvBrd

nervous system

spina bifida ( J:161417 )

• Background Sensitivity: in fewer mice than on a background without 129S5/SvEvBrd

limbs/digits/tail

abnormal limb development ( J:161417 )

• mice exhibit decreased cellular proliferation within the limb bud compared with wild-type mice

• however, apical ectodermal ridge specification is normal

craniofacial

small cranium ( J:161417 )

cardiovascular system

cardiovascular system phenotype ( J:161417 )

N • mice exhibit normal cardiovascular development

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:161417 )

N • ear development is normal

integument

pallor ( J:161417 )

• in mice that survive to E18.5

Genotype
MGI:2673595

hm2

• Allelic Composition: Med31^l11Jus15/Med31^l11Jus15
• Genetic Background: involves: C57BL/6J

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:85113 )

• homozygous embryos die between 13.5 and 18.5 dpc

embryo

embryonic growth retardation ( J:85113 )

open neural tube ( J:85113 )

• the neural tube is open in the rostral spinal cord region in 3 of 29 embryos examined

growth/size/body

abnormal embryonic growth/weight/body size ( J:85113 )

embryonic growth retardation ( J:85113 )

homeostasis/metabolism

edema ( J:85113 )

nervous system

open neural tube ( J:85113 )

• the neural tube is open in the rostral spinal cord region in 3 of 29 embryos examined