All Phenotypes Erbb2<l11Jus8> MGI Mouse

• mice die between E12.5 and E13

cardiovascular system phenotype ( J:222460 )

N	• at E12.5, mice exhibit normal atrioventricular cushion development and outflow tract vessel septation • mice exhibit normal heart ventricle morphology and conduction

• reduced vessel volume becoming progressively more severe from E11.5 to E12.5 in mice with thoracic hemorrhages

absent vitelline blood vessels ( J:222460 )

• by E12.5 in mice with thoracic hemorrhages

abnormal heart atrium morphology ( J:222460 )

• ubtle defects in atrial wall structure at E11.5

• at E11.5, 5 of 15 mice exhibit collapsing atria with reduced chamber lumen and thickening of irregularly folded myocardium

• thickened and irregularly folded in 5 of 15 mice at E11.5

• myocardium detaches from the epi- and endocardium at E12.5

dilated heart atrium ( J:222460 )

• distended

hemorrhage ( J:222460 )

• severe head and thoracic hemorrhage

atrioventricular block ( J:222460 )

• partial atrioventricular block with partial or full atrial block

• reduced vessel volume becoming progressively more severe from E11.5 to E12.5 in mice with thoracic hemorrhages

absent vitelline blood vessels ( J:222460 )

• by E12.5 in mice with thoracic hemorrhages

• thickened and irregularly folded in 5 of 15 mice at E11.5

• myocardium detaches from the epi- and endocardium at E12.5

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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