Phenotypes associated with this allele

• Allele Symbol: Mllt3^tm2Thr
• Allele Name: targeted mutation 2, Terence H Rabbitts
• Allele ID: MGI:2670765
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kmt2a^tm1Thr/Kmt2a^+ Mllt3^tm2Thr/Mllt3^+ Tg(Lck-cre)1Thr/?	involves: 129S/SvEv	MGI:3720075

Genotype
MGI:3720075

cn1

• Allelic Composition: Kmt2a^tm1Thr/Kmt2a⁺; Mllt3^tm2Thr/Mllt3⁺; Tg(Lck-cre)1Thr/?
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased hemolymphoid system tumor incidence ( J:100794 )

• 18 of 20 mice develop hematopoeitic neoplasm that are either T cell or myeloid in origin

• infiltration of malignant cells occurs in the liver, kidney, lungs and lymph nodes

increased T cell derived lymphoma incidence ( J:100794 )

• mice develop small T cell lymphomas

increased leukemia incidence ( J:100794 )

• mice have myelo-proliferative-like myeloid leukemia without circulating leukemic cells

hematopoietic system

enlarged spleen ( J:100794 )

• splenomeglia is caused by a repopulation of the spleen with malignant cells

abnormal spleen red pulp morphology ( J:100794 )

• red and white pulp architecture is lost

abnormal spleen white pulp morphology ( J:100794 )

• red and white pulp architecture is lost

immune system

enlarged spleen ( J:100794 )

• splenomeglia is caused by a repopulation of the spleen with malignant cells

abnormal spleen red pulp morphology ( J:100794 )

• red and white pulp architecture is lost

abnormal spleen white pulp morphology ( J:100794 )

• red and white pulp architecture is lost

growth/size/body

enlarged spleen ( J:100794 )

• splenomeglia is caused by a repopulation of the spleen with malignant cells

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:100794 )

• mice develop small T cell lymphomas