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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kmt2atm1Thr
targeted mutation 1, Terence H Rabbitts
MGI:2670764
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lmo2tm2(cre)Thr/Lmo2+
Kmt2atm1Thr/Kmt2a+
Mllt1tm1Thr/Mllt1+ 		involves: 129S/SvEv MGI:2671953
cn2
 		Kmt2atm1Thr/Kmt2a+
Mllt3tm2Thr/Mllt3+
Tg(Lck-cre)1Thr/? 		involves: 129S/SvEv MGI:3720075
cn3
 		Kmt2atm1Thr/Kmt2a+
Mllt1tm1Thr/Mllt1+
Tg(Lck-cre)1Thr/? 		involves: 129S/SvEv MGI:3720076


Genotype
MGI:2671953
cn1
Allelic
Composition		 Lmo2tm2(cre)Thr/Lmo2+
Kmt2atm1Thr/Kmt2a+
Mllt1tm1Thr/Mllt1+
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2atm1Thr mutation (0 available); any Kmt2a mutation (135 available)
Lmo2tm2(cre)Thr mutation (0 available); any Lmo2 mutation (31 available)
Mllt1tm1Thr mutation (0 available); any Mllt1 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:84518 )
• 100% of mutants either die or are sacrified due to ill health by 120 days of age

neoplasm
increased hemolymphoid system tumor incidence ( J:100794 )
• all mice develop hematological malignancies
• infiltration of malignant cells occurs in the liver, kidney, lungs and lymph nodes
increased leukemia incidence ( J:84518 , J:100794 )
• develop myeloid leukemias as early as 1.5 months of age (J:84518)
• leukemic cells invade the spleen and into peripheral organs such as liver and kidneys with perivascular deposits of tumor cells in liver and in between glomerili of kidney (J:84518)
• mice have myelo-proliferative-like myeloid leukemia (J:100794)

hematopoietic system
enlarged spleen ( J:84518 , J:100794 )
• splenomeglia is caused by a repopulation of the spleen with malignant cells (J:100794)
abnormal spleen red pulp morphology ( J:100794 )
• red and white pulp architecture is lost
abnormal spleen white pulp morphology ( J:100794 )
• red and white pulp architecture is lost

immune system
enlarged spleen ( J:84518 , J:100794 )
• splenomeglia is caused by a repopulation of the spleen with malignant cells (J:100794)
abnormal spleen red pulp morphology ( J:100794 )
• red and white pulp architecture is lost
abnormal spleen white pulp morphology ( J:100794 )
• red and white pulp architecture is lost

liver/biliary system

renal/urinary system

growth/size/body
enlarged spleen ( J:84518 , J:100794 )
• splenomeglia is caused by a repopulation of the spleen with malignant cells (J:100794)




Genotype
MGI:3720075
cn2
Allelic
Composition		 Kmt2atm1Thr/Kmt2a+
Mllt3tm2Thr/Mllt3+
Tg(Lck-cre)1Thr/?
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2atm1Thr mutation (0 available); any Kmt2a mutation (135 available)
Mllt3tm2Thr mutation (0 available); any Mllt3 mutation (31 available)
Tg(Lck-cre)1Thr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased hemolymphoid system tumor incidence ( J:100794 )
• 18 of 20 mice develop hematopoeitic neoplasm that are either T cell or myeloid in origin
• infiltration of malignant cells occurs in the liver, kidney, lungs and lymph nodes
increased T cell derived lymphoma incidence ( J:100794 )
• mice develop small T cell lymphomas
increased leukemia incidence ( J:100794 )
• mice have myelo-proliferative-like myeloid leukemia without circulating leukemic cells

hematopoietic system
enlarged spleen ( J:100794 )
• splenomeglia is caused by a repopulation of the spleen with malignant cells
abnormal spleen red pulp morphology ( J:100794 )
• red and white pulp architecture is lost
abnormal spleen white pulp morphology ( J:100794 )
• red and white pulp architecture is lost

immune system
enlarged spleen ( J:100794 )
• splenomeglia is caused by a repopulation of the spleen with malignant cells
abnormal spleen red pulp morphology ( J:100794 )
• red and white pulp architecture is lost
abnormal spleen white pulp morphology ( J:100794 )
• red and white pulp architecture is lost

growth/size/body
enlarged spleen ( J:100794 )
• splenomeglia is caused by a repopulation of the spleen with malignant cells

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:100794 )
• mice develop small T cell lymphomas




Genotype
MGI:3720076
cn3
Allelic
Composition		 Kmt2atm1Thr/Kmt2a+
Mllt1tm1Thr/Mllt1+
Tg(Lck-cre)1Thr/?
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2atm1Thr mutation (0 available); any Kmt2a mutation (135 available)
Mllt1tm1Thr mutation (0 available); any Mllt1 mutation (21 available)
Tg(Lck-cre)1Thr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:100794 )
N
• no hematological malignancies are observed




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory