Phenotypes associated with this allele

• Allele Symbol: Tg(HD82Gln)81Gschi
• Allele Name: transgene insertion 81, Gabriele Schilling
• Allele ID: MGI:2670626
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cnr1^tm1Map/Cnr1^tm1Map Tg(HD82Gln)81Gschi/0	involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * CD-1	MGI:5052307
tg2	Tg(HD82Gln)81Gschi/0	involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * CD-1	MGI:5052308
tg3	Tg(HD82Gln)81Gschi/0	involves: C3H/HeJ * C57BL/6	MGI:2671158

Genotype
MGI:5052307

cx1

• Allelic Composition: Cnr1^tm1Map/Cnr1^tm1Map; Tg(HD82Gln)81Gschi/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:172874 )

• reduced lifespan compared to wild-type controls

• however lifespan is similar to transgenic mice wild-type for Cnr1

nervous system

abnormal striatum morphology ( J:172874 )

• increase in the density of ubiquitin positive aggregates in the striatum compared to transgenic mice wild-type for Cnr1

behavior/neurological

impaired coordination ( J:172874 )

• reduced latency to fall and an increased number of falls in a rotarod assay

• motor performance is worse than in transgenic mice wild-type for Cnr1

growth/size/body

decreased body weight ( J:172874 )

• fail to gain weight after 16 weeks of age

abnormal postnatal growth ( J:172874 )

• fail to gain weight after 16 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Huntington's disease		DOID:12858	OMIM:143100	J:172874

Genotype
MGI:5052308

tg2

• Allelic Composition: Tg(HD82Gln)81Gschi/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * CD-1

mortality/aging

premature death ( J:172874 )

• reduced lifespan compared to wild-type controls

nervous system

abnormal striatum morphology ( J:172874 )

• ubiquitin positive aggregates in the striatum

behavior/neurological

impaired coordination ( J:172874 )

• reduced latency to fall and an increased number of falls in a rotarod assay from 14 weeks of age

growth/size/body

decreased body weight ( J:172874 )

• fail to gain weight after 16 weeks of age

abnormal postnatal growth ( J:172874 )

• fail to gain weight after 16 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Huntington's disease		DOID:12858	OMIM:143100	J:172874

Genotype
MGI:2671158

tg3

• Allelic Composition: Tg(HD82Gln)81Gschi/0
• Genetic Background: involves: C3H/HeJ * C57BL/6

mortality/aging

premature death ( J:53797 )

• lifespan is approximately 5-6 months

behavior/neurological

poor grooming ( J:53797 )

• endstage mice exhibit poor grooming

limb grasping ( J:53797 )

tremors ( J:53797 )

impaired coordination ( J:53797 )

• impaired performance on the rotarod

abnormal gait ( J:53797 )

bradykinesia ( J:53797 )

nervous system

abnormal hypothalamus morphology ( J:84682 )

• degeneration of hypothalamic neurons

neuronal intranuclear inclusions ( J:53797 )

• nuclear inclusions are observed in the cortex and caudate by immunocytochemistry

neurodegeneration ( J:84682 )

• degeneration of neurons in various hypothalamic areas including the lateral hypothalamus, the ventromedial hypothalamic nucleus, and the and the paraventricular nuclei

growth/size/body

decreased body size ( J:53797 )

• in the last 4 weeks of life, mutants are much smaller than controls

decreased body weight ( J:53797 )

• beginning at 2 months of age, mutants fail to gain weight

• weight loss is observed in the last 4-6 weeks before death

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Huntington's disease		DOID:12858	OMIM:143100	J:53797