Phenotypes associated with this allele

• Allele Symbol: Glce^tm1Jpli
• Allele Name: targeted mutation 1, Jin-Ping Li
• Allele ID: MGI:2670565
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Glce^tm1Jpli/Glce^tm1Jpli	involves: 129S1/Sv * 129X1/SvJ	MGI:2670566

Genotype
MGI:2670566

hm1

• Allelic Composition: Glce^tm1Jpli/Glce^tm1Jpli
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Kidney, lung, eye, skeletal and tail abnormalities in E18.5 Glce^tm1Jpli/Glce^tm1Jpli mice

mortality/aging

neonatal lethality, complete penetrance ( J:84695 )

• mice die immediately after birth from respiratory failure

growth/size/body

cleft palate ( J:84695 )

• seen often in mutants

decreased body length ( J:84695 )

respiratory system

abnormal lung morphology ( J:84695 )

• lungs are poorly inflated and immature

increased pulmonary alveolus wall thickness ( J:84695 )

• thickened, cell-rich alveolar walls

respiratory failure ( J:84695 )

renal/urinary system

absent kidney ( J:84695 )

vision/eye

iris coloboma ( J:84695 )

• bilateral iris coloboma

skeleton

abnormal phalanx morphology ( J:84695 )

• lack proximal phalanges

absent tarsus bones ( J:84695 )

• lack tarsal bones

abnormal thoracic cage morphology ( J:84695 )

abnormal sternum morphology ( J:84695 )

abnormal skeleton development ( J:84695 )

• congenital skeletal deformatiies

abnormal bone mineralization ( J:84695 )

• excessive bone mineralization

limbs/digits/tail

abnormal phalanx morphology ( J:84695 )

• lack proximal phalanges

polydactyly ( J:84695 )

• post-axial polydactyly in one or both forelimbs

absent tarsus bones ( J:84695 )

• lack tarsal bones

curly tail ( J:84695 )

• twisted tail

craniofacial

cleft palate ( J:84695 )

• seen often in mutants

digestive/alimentary system

cleft palate ( J:84695 )

• seen often in mutants