Phenotypes associated with this allele

• Allele Symbol: Thra^tm3Jas
• Allele Name: targeted mutation 1, Jacques Samarut
• Allele ID: MGI:2670368
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Thra^tm3Jas/Thra^tm3Jas	involves: 129	MGI:2670421

Genotype
MGI:2670421

hm1

• Allelic Composition: Thra^tm3Jas/Thra^tm3Jas
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestine goblet cell morphology ( J:84537 )

• increase in the number of goblet cells in the ileum, however no other morphological abnormalities in the intestine

abnormal enterocyte physiology ( J:84537 )

• enterocyte sucrase enzyme activity is decreased to less than 35% of wild-type

abnormal enterocyte proliferation ( J:84537 )

• administration of T3 to induce hyperthyroidism stimulates higher proliferation of crypt cells compared to wild-type, despite similar blood concentrations of T3

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:84537 )

• enterocyte sucrase enzyme activity is decreased to less than 35% of wild-type

cellular

abnormal intestine goblet cell morphology ( J:84537 )

• increase in the number of goblet cells in the ileum, however no other morphological abnormalities in the intestine

abnormal enterocyte proliferation ( J:84537 )

• administration of T3 to induce hyperthyroidism stimulates higher proliferation of crypt cells compared to wild-type, despite similar blood concentrations of T3