Phenotypes associated with this allele

• Allele Symbol: Txn1^tm1Mmt
• Allele Name: targeted mutation 1, Maketo M Taketo
• Allele ID: MGI:2669963
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Txn1^tm1Mmt/Txn1^tm1Mmt	involves: 129S2/SvPas * C57BL/6	MGI:2675310

Genotype
MGI:2675310

hm1

• Allelic Composition: Txn1^tm1Mmt/Txn1^tm1Mmt
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:35059 )

• homozygous embryos die shortly after implantation

embryo

absent inner cell mass proliferation ( J:35059 )

• the inner cell mass did not proliferate

failure of blastocyst to hatch from the zona pellucida ( J:35059 )

• embryos failed to hatch from the zona pellucida

embryonic growth arrest ( J:35059 )

• embryos failed to hatch from the zona pellucida and exhibited a retarded morphology at E3.5

abnormal trophoblast layer morphology ( J:35059 )

• trophoblasts exhibited poor attachment and outgrowth

cellular

absent inner cell mass proliferation ( J:35059 )

• the inner cell mass did not proliferate