Phenotypes associated with this allele

• Allele Symbol: Ighg1^tm1Ksho
• Allele Name: targeted mutation 1, Tsuneyasu Kaisho
• Allele ID: MGI:2669500
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ighg1^tm1Ksho/Ighg1^tm1Ksho	involves: 129P2/OlaHsd * C57BL/6	MGI:2669514
ht2	Ighg1^tm1Ksho/Ighg1^+	involves: 129P2/OlaHsd * C57BL/6	MGI:2669548

Genotype
MGI:2669514

hm1

• Allelic Composition: Ighg1^tm1Ksho/Ighg1^tm1Ksho
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

absent memory B cells ( J:39568 )

• mice lack IgG1-bearing memory B cells

abnormal B cell physiology ( J:39568 )

• mutants immunized with NP-CG produce strongly impaired primary and secondary IgG1 responses, about one order of magnitude below the controls

• affinity maturation of IgG1 antibodies in the course of the response is less efficient in mutants

decreased IgG1 level ( J:39568 )

• serum NP-specific IgG1 concentration is reduced by a factor of 24 in mutants immunized with a T cell-dependent antigen, chicken gamma-globulin coupled to 4-hydroxy-3-nitro-phenylacetyl (NP-CG)

immune system

absent memory B cells ( J:39568 )

• mice lack IgG1-bearing memory B cells

abnormal B cell physiology ( J:39568 )

• mutants immunized with NP-CG produce strongly impaired primary and secondary IgG1 responses, about one order of magnitude below the controls

• affinity maturation of IgG1 antibodies in the course of the response is less efficient in mutants

decreased IgG1 level ( J:39568 )

• serum NP-specific IgG1 concentration is reduced by a factor of 24 in mutants immunized with a T cell-dependent antigen, chicken gamma-globulin coupled to 4-hydroxy-3-nitro-phenylacetyl (NP-CG)

Genotype
MGI:2669548

ht2

• Allelic Composition: Ighg1^tm1Ksho/Ighg1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

immune system

abnormal B cell physiology ( J:39568 )

• B cells are unable to mount efficient primary and secondary IgG1 responses

• the impairment is less pronounced than in Ighg1^tm1.1Ksho homozygotes

decreased IgG1 level ( J:39568 )

• mutants immunized with a T cell-dependent antigen, chicken gamma-globulin coupled to 4-hydroxy-3-nitro-phenylacetyl (NP-CG), produce less NP-specific IgG1

hematopoietic system

abnormal B cell physiology ( J:39568 )

• B cells are unable to mount efficient primary and secondary IgG1 responses

• the impairment is less pronounced than in Ighg1^tm1.1Ksho homozygotes

decreased IgG1 level ( J:39568 )

• mutants immunized with a T cell-dependent antigen, chicken gamma-globulin coupled to 4-hydroxy-3-nitro-phenylacetyl (NP-CG), produce less NP-specific IgG1