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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Runx1tm2Spe
targeted mutation 2, Nancy A Speck
MGI:2668479
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Runx1tm1Spe/Runx1tm2Spe either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6) MGI:2671954
ht2
 		Runx1tm1Yg/Runx1tm2Spe either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1) MGI:3760802
cn3
 		Runx1tm2Spe/Runx1tm3Spe
Tg(KRT5-cre)5132Jlj/0 		either: (involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2J) or (involves: 129S4/SvJae * C57BL/6 * DBA/2J) MGI:3709862


Genotype
MGI:2671954
ht1
Allelic
Composition		 Runx1tm1Spe/Runx1tm2Spe
Genetic
Background		 either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm1Spe mutation (1 available); any Runx1 mutation (35 available)
Runx1tm2Spe mutation (0 available); any Runx1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal embryonic hematopoiesis ( J:56184 )
• absence of hematopoietic colonies in fetal livers, vitelline and umbilical arteries
• no fetal liver hematopoiesis
• no yolk sac hematopoiesis

embryo
abnormal embryonic hematopoiesis ( J:56184 )
• absence of hematopoietic colonies in fetal livers, vitelline and umbilical arteries
• no fetal liver hematopoiesis
• no yolk sac hematopoiesis




Genotype
MGI:3760802
ht2
Allelic
Composition		 Runx1tm1Yg/Runx1tm2Spe
Genetic
Background		 either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm1Yg mutation (2 available); any Runx1 mutation (35 available)
Runx1tm2Spe mutation (0 available); any Runx1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:125830 )
• mice die between E11.5 and E12.5 of hemorrhages in the central nervous system

cardiovascular system
internal hemorrhage ( J:125830 )
• mice die of hemorrhages in the central nervous system extensively in the fourth ventricle, ventral metencephalon and spinal cord

nervous system




Genotype
MGI:3709862
cn3
Allelic
Composition		 Runx1tm2Spe/Runx1tm3Spe
Tg(KRT5-cre)5132Jlj/0
Genetic
Background		 either: (involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2J) or (involves: 129S4/SvJae * C57BL/6 * DBA/2J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm2Spe mutation (0 available); any Runx1 mutation (35 available)
Runx1tm3Spe mutation (0 available); any Runx1 mutation (35 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
increased curvature of auchene hairs ( J:116050 )
• majority of auchene hair type are altered in shape, many with more pronounced bends
abnormal coat appearance ( J:116050 )
• adult coat appears less dense and ruffled than controls
abnormal zigzag hair morphology ( J:116050 )
• about 90% of zigzag (ZZ) type hair show much less pronounced bends in 6-month old adults
• hair forms exhibit a variable number of bends compared to the three bend in control hairs; many do not have alternating bend patterns of control hairs, but have 2 bends in same direction
decreased curvature of zigzag hairs ( J:116050 )
• ~90% of zigzag (ZZ) type hair shows much less pronounced bends in 6-month old adults




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory