About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Runx1tm2Spe
targeted mutation 2, Nancy A Speck
MGI:2668479
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Runx1tm1Spe/Runx1tm2Spe either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6) MGI:2671954
ht2
 		Runx1tm1Yg/Runx1tm2Spe either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1) MGI:3760802
cn3
 		Runx1tm2Spe/Runx1tm3Spe
Tg(KRT5-cre)5132Jlj/0 		either: (involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2J) or (involves: 129S4/SvJae * C57BL/6 * DBA/2J) MGI:3709862


Genotype
MGI:2671954
ht1
Allelic
Composition		 Runx1tm1Spe/Runx1tm2Spe
Genetic
Background		 either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm1Spe mutation (1 available); any Runx1 mutation (34 available)
Runx1tm2Spe mutation (0 available); any Runx1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal embryonic hematopoiesis ( J:56184 )
• absence of hematopoietic colonies in fetal livers, vitelline and umbilical arteries
• no fetal liver hematopoiesis
• no yolk sac hematopoiesis

embryo
abnormal embryonic hematopoiesis ( J:56184 )
• absence of hematopoietic colonies in fetal livers, vitelline and umbilical arteries
• no fetal liver hematopoiesis
• no yolk sac hematopoiesis




Genotype
MGI:3760802
ht2
Allelic
Composition		 Runx1tm1Yg/Runx1tm2Spe
Genetic
Background		 either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm1Yg mutation (2 available); any Runx1 mutation (34 available)
Runx1tm2Spe mutation (0 available); any Runx1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:125830 )
• mice die between E11.5 and E12.5 of hemorrhages in the central nervous system

cardiovascular system
internal hemorrhage ( J:125830 )
• mice die of hemorrhages in the central nervous system extensively in the fourth ventricle, ventral metencephalon and spinal cord

nervous system




Genotype
MGI:3709862
cn3
Allelic
Composition		 Runx1tm2Spe/Runx1tm3Spe
Tg(KRT5-cre)5132Jlj/0
Genetic
Background		 either: (involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2J) or (involves: 129S4/SvJae * C57BL/6 * DBA/2J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm2Spe mutation (0 available); any Runx1 mutation (34 available)
Runx1tm3Spe mutation (0 available); any Runx1 mutation (34 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
increased curvature of auchene hairs ( J:116050 )
• majority of auchene hair type are altered in shape, many with more pronounced bends
abnormal coat appearance ( J:116050 )
• adult coat appears less dense and ruffled than controls
abnormal zigzag hair morphology ( J:116050 )
• about 90% of zigzag (ZZ) type hair show much less pronounced bends in 6-month old adults
• hair forms exhibit a variable number of bends compared to the three bend in control hairs; many do not have alternating bend patterns of control hairs, but have 2 bends in same direction
decreased curvature of zigzag hairs ( J:116050 )
• ~90% of zigzag (ZZ) type hair shows much less pronounced bends in 6-month old adults




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory