Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad2tm2Rob mutation
(1 available);
any
Smad2 mutation
(50 available)
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normal phenotype
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• mice are viable and fertile
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embryo
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• at E8.5, rostral neurectoderm tissue is reduced in size
• at E9.5, anterior neurectoderm fails to proliferate and is filled with pyknotic nuclei
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• there are reduced numbers of anterior definitive endoderm (ADE) cells
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digestive/alimentary system
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• gut tube forms but is poorly elaborated in anterior region; instead of extending to level of Rathke's pouch like wild-type, no gut tissue is evident at this level in mutants and is absent anterior to level of heart
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cardiovascular system
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• heart tube is abnormally looped
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• pericardium is often edematous
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• pericardium is often enlarged
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nervous system
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• embryos lack all prospective midbrain tissue
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• embryos lack all prospective forebrain tissue
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homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation
(5 available);
any
Edil3 mutation
(42 available)
Smad2tm1Rob mutation
(0 available);
any
Smad2 mutation
(50 available)
Smad2tm2Rob mutation
(1 available);
any
Smad2 mutation
(50 available)
Smad3tm1Xfw mutation
(0 available);
any
Smad3 mutation
(18 available)
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embryo
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• embryos develop severe anterior truncations at E8.5
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• somites are fused across the midline at E8.5
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digestive/alimentary system
cardiovascular system
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• embryos develop heart malformations at E8.5
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