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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dclre1ctm1.1Fwa
targeted mutation 1.1, Frederick W Alt
MGI:2667616
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dclre1ctm1.1Fwa/Dclre1ctm1.1Fwa involves: 129S6/SvEvTac * C57BL/6 MGI:2667619


Genotype
MGI:2667619
hm1
Allelic
Composition		 Dclre1ctm1.1Fwa/Dclre1ctm1.1Fwa
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclre1ctm1.1Fwa mutation (0 available); any Dclre1c mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested B cell differentiation ( J:80995 )
• block at a progenitor stage when Ig rearrangements first occur
arrested T cell differentiation ( J:80995 )
• T cell development is partially blocked at the CD4-CD8- double negative progenitor stage when Tcr rearrangements first occur

immune system
arrested B cell differentiation ( J:80995 )
• block at a progenitor stage when Ig rearrangements first occur
arrested T cell differentiation ( J:80995 )
• T cell development is partially blocked at the CD4-CD8- double negative progenitor stage when Tcr rearrangements first occur




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory