Phenotypes associated with this allele

• Allele Symbol: Tg(Krt14-dnLef1)LFmw
• Allele Name: transgene insertion L, Fiona M Watt
• Allele ID: MGI:2667375
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Krt14-dnLef1)LFmw/?	involves: C57BL/6 * CBA	MGI:2667413

Genotype
MGI:2667413

tg1

• Allelic Composition: Tg(Krt14-dnLef1)LFmw/?
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased skin tumor incidence ( J:73649 )

• mice developed spontaneous skin tumors starting at 3 months of age

• tumor growth was quick and mice were sacrificed within 2 - 3 weeks of tumor onset

integument

alopecia ( J:73649 )

• observed at 6 weeks of age, when hair appeared progressively sparser than littermate controls

• hair was thinner with each progressive hair cycle, and by ten months of age the mice were almost completely bald

abnormal hair follicle orientation ( J:73649 )

• transgenic mice exhibited an abnormal orientationof hair follicles during anagen of the first postnatal hair cycle

sparse vibrissae ( J:73649 )

• observed at 6 weeks of age, when whickers appeared progressively sparser than littermate controls

abnormal skin condition ( J:73649 )

• concomitant with hair loss, at 6 weeks of age mice developed small while lumps of the skin all over the body

epithelioid cyst ( J:73649 )

• the cysts were derived from the base of hair follicles and expressed markers of interfollicular epidermis.

thick skin ( J:73649 )

• the epidermis of transgenic animals was slightly thicker than wild-type

increased skin tumor incidence ( J:73649 )

• mice developed spontaneous skin tumors starting at 3 months of age

• tumor growth was quick and mice were sacrificed within 2 - 3 weeks of tumor onset

growth/size/body

epithelioid cyst ( J:73649 )

• the cysts were derived from the base of hair follicles and expressed markers of interfollicular epidermis.