Phenotypes associated with this allele

• Allele Symbol: Rasgrf1^tm1Esn
• Allele Name: targeted mutation1, Eugenio Santos
• Allele ID: MGI:2667231
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rasgrf1^tm1Esn/Rasgrf1^tm1Esn	involves: 129/Sv * C57BL/6N	MGI:2669007

Genotype
MGI:2669007

hm1

• Allelic Composition: Rasgrf1^tm1Esn/Rasgrf1^tm1Esn
• Genetic Background: involves: 129/Sv * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased total body fat amount ( J:83950 )

• abdominal fat is reduced by about 30%

endocrine/exocrine glands

decreased pancreatic beta cell number ( J:83950 )

• beta cell number is reduced, not individual cell size, beta cell proliferation is reduced

small pancreatic islets ( J:83950 )

• islets are reduced in size and beta cell area is reduced by 30%

growth/size/body

decreased body weight ( J:83950 )

• both body size and weight are reduced to about 70% of wild-type

homeostasis/metabolism

decreased circulating insulin level ( J:83950 )

• insulin levels are reduced by about 30% (detectable by 6 weeks of age)

impaired glucose tolerance ( J:83950 )

• glucose intolerant; glucose tolerance tests demonstrated that there is a dampened glucose stimulated release of insulin early (15 min) but glucose levels return to normal by 120 minutes

enhanced lipolysis ( J:83950 )

• basal lipolysis levels in adipose tissues are 2X normal