Analysis Tools
hematopoietic system
| N |
• homozygotes display normal B cell production in the bone marrow, as shown by normal numbers of pro-B or pre-B cells and immature B cells
• T cell numbers remain normal
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• homozygotes display significantly reduced numbers of transitional T2 B cells in spleen relative to wild-type controls
• however, numbers of transitional T1 B cells are normal, suggesting that B cell emigration from the bone marrow is unaffected
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• homozygotes display a significant reduction in recirculating mature B cells in spleen, blood, and all peripheral lymph nodes relative to wild-type controls
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• homozygotes display significantly reduced numbers of mature B-2 B cells in spleen relative to wild-type controls
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• homozygotes show significantly reduced numbers of mature recirculating (follicular) B cells in spleen relative to wild-type controls
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• homozygotes show a 7-fold increase in the number of peritoneal B1 cells relative to wild-type controls
• in contrast, the number of peritoneal B-2 B cells is similar to that in wild-type controls
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• homozygotes exhibit an abnormal splenic mircoarchitecture relative to wild-type controls
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• homozygotes display significantly reduced numbers of marginal zone B cells in spleen relative to wild-type controls
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• only a few MOMA1+ marginal metallophilic macrophages are seen in the white pulp of mutant spleens
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• no follicular dendritic cell clusters are detected in mutant spleens
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• mutant B cell follicles are reduced to a small ring around an apparently normal T zone
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immune system
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• homozygotes display significantly reduced numbers of transitional T2 B cells in spleen relative to wild-type controls
• however, numbers of transitional T1 B cells are normal, suggesting that B cell emigration from the bone marrow is unaffected
|
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• homozygotes display a significant reduction in recirculating mature B cells in spleen, blood, and all peripheral lymph nodes relative to wild-type controls
|
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• homozygotes display significantly reduced numbers of mature B-2 B cells in spleen relative to wild-type controls
|
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• homozygotes show significantly reduced numbers of mature recirculating (follicular) B cells in spleen relative to wild-type controls
|
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• homozygotes show a 7-fold increase in the number of peritoneal B1 cells relative to wild-type controls
• in contrast, the number of peritoneal B-2 B cells is similar to that in wild-type controls
|
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• homozygotes exhibit an abnormal splenic mircoarchitecture relative to wild-type controls
|
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• homozygotes display significantly reduced numbers of marginal zone B cells in spleen relative to wild-type controls
|
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• only a few MOMA1+ marginal metallophilic macrophages are seen in the white pulp of mutant spleens
|
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• no follicular dendritic cell clusters are detected in mutant spleens
|
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• mutant B cell follicles are reduced to a small ring around an apparently normal T zone
|
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• homozygotes display small peripheral lymph nodes relative to wild-type controls
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