Phenotypes associated with this allele

• Allele Symbol: Foxf2^tm1Miu
• Allele Name: targeted mutation 1, Naoyuki Miura
• Allele ID: MGI:2667134
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxf2^tm1Miu/Foxf2^tm1Miu	involves: 129P2/OlaHsd * C57BL/6	MGI:2667135

Genotype
MGI:2667135

hm1

• Allelic Composition: Foxf2^tm1Miu/Foxf2^tm1Miu
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:84053 )

• all homozygotes die within 12-18 hrs of birth with meteorism

vision/eye

abnormal optic canal morphology ( J:84053 )

• formation of the optic canal, which is contiguous with the presphenoid bone, is impaired

behavior/neurological

absent gastric milk in neonates ( J:84053 )

abnormal suckling behavior ( J:84053 )

• shortly after birth, mutant pups are unable to suckle, as evidenced by the absence of milk in their stomachs

growth/size/body

abnormal maxillary shelf morphology ( J:84053 )

• newborn homozygotes display a lateral shift of the maxillary shelves

• the palatal processes of the maxillary are absent or malformed

abnormal palatine bone horizontal plate morphology ( J:84053 )

• the palatal processes of the palatine are absent or malformed

absent palatine bone horizontal plate ( J:84053 )

• the palatal processes of the palatine are absent or malformed

palatal shelves fail to meet at midline ( J:84053 )

• newborn homozygotes exhibit a failed fusion of palate shelves

absent soft palate ( J:84053 )

• newborn homozygotes display loss of the soft palate

cleft secondary palate ( J:84053 )

• all homozygotes show an extensive cleft of the secondary palate without other craniofacial defects

• as a result, mutant pups fail to develop negative pressure in the oral cavity and are unable to suckle

• however, the development of Meckel's cartilage and extent of cell proliferation during palatogenesis are normal

failure of palatal shelf elevation ( J:84053 )

• during palatogenesis, the tongue fails to descend and flatten to allow vertical-to-horizontal movement of the palatal shelves

abnormal tongue position ( J:84053 )

• during palatogenesis, the tongue fails to descend and flatten to allow vertical-to-horizontal movement of the palatal shelves

• as a result, the tongue is abnormally shaped and partially located between the two palate shelves, physically obstructing the normal fusion of palatal shelves observed in wild-type mice

meteorism ( J:84053 )

• homozygotes display meteorism i.e. an abnormally distended GI tract filled by pockets of gas and fluid within 12 hrs of birth

• the flatus first appears in the stomach, enters the intestinal tract, and eventually fills the entire GI tract

craniofacial

abnormal optic canal morphology ( J:84053 )

• formation of the optic canal, which is contiguous with the presphenoid bone, is impaired

abnormal presphenoid bone morphology ( J:84053 )

• ossification of the presphenoid bone is defective due to secondary effects of the cleft palate

abnormal pterygoid bone morphology ( J:84053 )

• the pterygoid bone is absent or malformed

abnormal maxillary shelf morphology ( J:84053 )

• newborn homozygotes display a lateral shift of the maxillary shelves

• the palatal processes of the maxillary are absent or malformed

abnormal palatine bone horizontal plate morphology ( J:84053 )

• the palatal processes of the palatine are absent or malformed

absent palatine bone horizontal plate ( J:84053 )

• the palatal processes of the palatine are absent or malformed

palatal shelves fail to meet at midline ( J:84053 )

• newborn homozygotes exhibit a failed fusion of palate shelves

absent soft palate ( J:84053 )

• newborn homozygotes display loss of the soft palate

cleft secondary palate ( J:84053 )

• all homozygotes show an extensive cleft of the secondary palate without other craniofacial defects

• as a result, mutant pups fail to develop negative pressure in the oral cavity and are unable to suckle

• however, the development of Meckel's cartilage and extent of cell proliferation during palatogenesis are normal

failure of palatal shelf elevation ( J:84053 )

• during palatogenesis, the tongue fails to descend and flatten to allow vertical-to-horizontal movement of the palatal shelves

abnormal tongue position ( J:84053 )

• during palatogenesis, the tongue fails to descend and flatten to allow vertical-to-horizontal movement of the palatal shelves

• as a result, the tongue is abnormally shaped and partially located between the two palate shelves, physically obstructing the normal fusion of palatal shelves observed in wild-type mice

digestive/alimentary system

digestive/alimentary phenotype ( J:84053 )

N • although newborn homozygotes exhibit an air-distended GI tract, no morphological or functional abnormalities are observed in the foregut

abnormal maxillary shelf morphology ( J:84053 )

• newborn homozygotes display a lateral shift of the maxillary shelves

• the palatal processes of the maxillary are absent or malformed

abnormal palatine bone horizontal plate morphology ( J:84053 )

• the palatal processes of the palatine are absent or malformed

absent palatine bone horizontal plate ( J:84053 )

• the palatal processes of the palatine are absent or malformed

palatal shelves fail to meet at midline ( J:84053 )

• newborn homozygotes exhibit a failed fusion of palate shelves

absent soft palate ( J:84053 )

• newborn homozygotes display loss of the soft palate

cleft secondary palate ( J:84053 )

• all homozygotes show an extensive cleft of the secondary palate without other craniofacial defects

• as a result, mutant pups fail to develop negative pressure in the oral cavity and are unable to suckle

• however, the development of Meckel's cartilage and extent of cell proliferation during palatogenesis are normal

failure of palatal shelf elevation ( J:84053 )

• during palatogenesis, the tongue fails to descend and flatten to allow vertical-to-horizontal movement of the palatal shelves

abnormal tongue position ( J:84053 )

• during palatogenesis, the tongue fails to descend and flatten to allow vertical-to-horizontal movement of the palatal shelves

• as a result, the tongue is abnormally shaped and partially located between the two palate shelves, physically obstructing the normal fusion of palatal shelves observed in wild-type mice

meteorism ( J:84053 )

• homozygotes display meteorism i.e. an abnormally distended GI tract filled by pockets of gas and fluid within 12 hrs of birth

• the flatus first appears in the stomach, enters the intestinal tract, and eventually fills the entire GI tract

skeleton

abnormal optic canal morphology ( J:84053 )

• formation of the optic canal, which is contiguous with the presphenoid bone, is impaired

abnormal presphenoid bone morphology ( J:84053 )

• ossification of the presphenoid bone is defective due to secondary effects of the cleft palate

abnormal pterygoid bone morphology ( J:84053 )

• the pterygoid bone is absent or malformed

abnormal maxillary shelf morphology ( J:84053 )

• newborn homozygotes display a lateral shift of the maxillary shelves

• the palatal processes of the maxillary are absent or malformed

abnormal palatine bone horizontal plate morphology ( J:84053 )

• the palatal processes of the palatine are absent or malformed

absent palatine bone horizontal plate ( J:84053 )

• the palatal processes of the palatine are absent or malformed

respiratory system

respiratory system phenotype ( J:84053 )

N • newborn homozygotes display normal lung development with no significant alterations in differentiation and maturation of lung epithelial cells