Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-Zfpm2)1Sho
• Allele Name: transgene insertion 1, Stuart Orkin
• Allele ID: MGI:2665416
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Zfpm2^tm1Sho/Zfpm2^tm1Sho Tg(Myh6-Zfpm2)1Sho/0	involves: 129S1/Sv	MGI:2665480

Genotype
MGI:2665480

cx1

• Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm1Sho; Tg(Myh6-Zfpm2)1Sho/0
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:62879 )

• fetuses survive to about E17.5

cardiovascular system

cardiovascular system phenotype ( J:62879 )

N • at E15.5, mutant embryos are grossly normal and display normal coronary vasculogenesis

N • no ventricular wall thinning is observed

common atrioventricular valve ( J:62879 )

• a common atrioventricular valve is situated between the left and right ventricles

endocrine/exocrine glands

abnormal ovary morphology ( J:78688 )

abnormal Sertoli cell morphology ( J:78688 )

• blocked differentiation

abnormal Leydig cell differentiation ( J:78688 )

• maturation of Leydig cells was not initiated

reproductive system

abnormal ovary morphology ( J:78688 )

abnormal Sertoli cell morphology ( J:78688 )

• blocked differentiation

abnormal Leydig cell differentiation ( J:78688 )

• maturation of Leydig cells was not initiated

abnormal primary sex determination ( J:78688 )

• XX mice have abnormal ovaries; details not given

• gonads of XY mice are abnormal

primary sex reversal ( J:78688 )

• gonads have ovarian shape and location at E17.5, germ cells and vasculature present but no testicular cords