Phenotypes associated with this allele

• Allele Symbol: Klf4^tm1.1Khk
• Allele Name: targeted mutation 1.1, Klaus H Kaestner
• Allele ID: MGI:2664975
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klf4^tm1.1Khk/Klf4^tm1.1Khk	involves: 129S6/SvEvTac * C57BL/6	MGI:2664976

Genotype
MGI:2664976

hm1

• Allelic Composition: Klf4^tm1.1Khk/Klf4^tm1.1Khk
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:76493 )

• death within 15 hours of birth

digestive/alimentary system

abnormal colon goblet cell morphology ( J:76493 )

• 90% decrease in the number of mature goblet cells relative to wild-type

• normal numbers and differentiation of colonocytes and enteroendocrine cells

• normal cell proliferation and cell death rates in the colon on postnatal day 1

abnormal intestinal epithelium morphology ( J:76493 )

• defective differentiation of colonic epithelium

endocrine/exocrine glands

abnormal colon goblet cell morphology ( J:76493 )

• 90% decrease in the number of mature goblet cells relative to wild-type

• normal numbers and differentiation of colonocytes and enteroendocrine cells

• normal cell proliferation and cell death rates in the colon on postnatal day 1

cellular

abnormal colon goblet cell morphology ( J:76493 )

• 90% decrease in the number of mature goblet cells relative to wild-type

• normal numbers and differentiation of colonocytes and enteroendocrine cells

• normal cell proliferation and cell death rates in the colon on postnatal day 1