Phenotypes associated with this allele

• Allele Symbol: Tmod2^tm1Hzo
• Allele Name: targeted mutation 1, Huda Y Zoghbi
• Allele ID: MGI:2664500
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmod2^tm1Hzo/Tmod2^tm1Hzo	involves: 129S7/SvEvBrd * C57BL/6J	MGI:2664501

Genotype
MGI:2664501

hm1

• Allelic Composition: Tmod2^tm1Hzo/Tmod2^tm1Hzo
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal contextual conditioning behavior ( J:83752 )

• in the conditioned fear test, mutants show less freezing in the presence of the contextual cues during training

abnormal cued conditioning behavior ( J:83752 )

• in the conditioned fear test, mutants show less freezing in the presence of auditory cues during training

impaired coordination ( J:83752 )

• mutants have a tendency to spend less time on the rotating rod than wild-type, suggesting a mild coordination impairment

increased vertical activity ( J:83752 )

increased locomotor activity ( J:83752 )

• mutants are hyperactive in the open-field test, going further and traveling faster than wild-type mice

nervous system

enhanced long-term potentiation ( J:83752 )

• mutants exhibit enhancement of LTP during the 60 min following tetanus