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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Spp1Ric-r
rickettsia tsutsugamushi resistant
MGI:2663657
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Spp1Ric-r/Spp1+ A/J MGI:3721545
ht2
 		Spp1Ric-r/Spp1+ AKR/J MGI:3721544
ht3
 		Spp1Ric-r/Spp1+ BALB/cJ MGI:3721547
ht4
 		Spp1Ric-r/Spp1+ C3H/Rv MGI:3721565
ht5
 		Spp1Ric-r/Spp1+ C57BL/6J MGI:3721549
ht6
 		Spp1Ric-r/Spp1+ C57L/J MGI:3721550
ht7
 		Spp1Ric-r/Spp1+ SWR/J MGI:3721553


Genotype
MGI:3721545
ht1
Allelic
Composition		 Spp1Ric-r/Spp1+
Genetic
Background		 A/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1Ric-r mutation (0 available); any Spp1 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to bacterial infection ( J:5949 )
• mice are selectively resistant to Rickettsia tsutsugamushi infection




Genotype
MGI:3721544
ht2
Allelic
Composition		 Spp1Ric-r/Spp1+
Genetic
Background		 AKR/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1Ric-r mutation (0 available); any Spp1 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to bacterial infection ( J:5949 )
• mice are resistant to Rickettsia tsutsugamushi infection




Genotype
MGI:3721547
ht3
Allelic
Composition		 Spp1Ric-r/Spp1+
Genetic
Background		 BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1Ric-r mutation (0 available); any Spp1 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to bacterial infection ( J:5949 )
• mice are resistant to Rickettsia tsutsugamushi infection




Genotype
MGI:3721565
ht4
Allelic
Composition		 Spp1Ric-r/Spp1+
Genetic
Background		 C3H/Rv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1Ric-r mutation (0 available); any Spp1 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to bacterial infection induced morbidity/mortality ( J:7240 )
• mice do not die following Rickettsia tsutsugamushi infection

immune system
increased macrophage cell number ( J:7240 )
• following Rickettsia tsutsugamushi infection, there is an increase in Ia+ macrophages in peritoneum exudate
decreased susceptibility to bacterial infection induced morbidity/mortality ( J:7240 )
• mice do not die following Rickettsia tsutsugamushi infection

hematopoietic system
increased macrophage cell number ( J:7240 )
• following Rickettsia tsutsugamushi infection, there is an increase in Ia+ macrophages in peritoneum exudate




Genotype
MGI:3721549
ht5
Allelic
Composition		 Spp1Ric-r/Spp1+
Genetic
Background		 C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1Ric-r mutation (0 available); any Spp1 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to bacterial infection ( J:5949 )
• mice are resistant to Rickettsia tsutsugamushi infection




Genotype
MGI:3721550
ht6
Allelic
Composition		 Spp1Ric-r/Spp1+
Genetic
Background		 C57L/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1Ric-r mutation (0 available); any Spp1 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to bacterial infection ( J:5949 )
• mice are resistant to Rickettsia tsutsugamushi infection




Genotype
MGI:3721553
ht7
Allelic
Composition		 Spp1Ric-r/Spp1+
Genetic
Background		 SWR/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1Ric-r mutation (0 available); any Spp1 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to bacterial infection ( J:5949 )
• mice are resistant to Rickettsia tsutsugamushi infection




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory