Phenotypes associated with this allele

• Allele Symbol: Pdgfra^{tm11(EGFP)Sor}
• Allele Name: targeted mutation 11, Philippe Soriano
• Allele ID: MGI:2663656
• Summary: 8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdgfra^tm11(EGFP)Sor/Pdgfra^tm11(EGFP)Sor	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:5519063
ht2	Pdgfra^tm10(Pdgfra/tor)Sor/Pdgfra^tm11(EGFP)Sor	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:2663660
ht3	Pdgfra^tm9(Pdgfra/Fgfr1)Sor/Pdgfra^tm11(EGFP)Sor	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:2663664
ht4	Pdgfra^tm6Sor/Pdgfra^tm11(EGFP)Sor	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)	MGI:3694484
ht5	Pdgfra^tm5Sor/Pdgfra^tm11(EGFP)Sor	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)	MGI:3694482
cx6	Gata6^tm2.2Sad/Gata6^tm2.2Sad Pdgfra^tm11(EGFP)Sor/Pdgfra^+	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ	MGI:5780588
cx7	Pdgfa^tm1Cbet/Pdgfa^tm2Cbet Pdgfra^tm11(EGFP)Sor/Pdgfra^+	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6	MGI:5548177
cx8	Hoxa5^tm1Rob/Hoxa5^tm1Rob Pdgfra^tm11(EGFP)Sor/Pdgfra^+	involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * MF1	MGI:4941631

Genotype
MGI:5519063

hm1

• Allelic Composition: Pdgfra^{tm11(EGFP)Sor}/Pdgfra^{tm11(EGFP)Sor}
• Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality ( J:83560 )

embryo

abnormal placenta vasculature ( J:83560 )

• vascular development in the chorioallantoic plate is retarded

abnormal placenta development ( J:83560 )

• the epithelial cell layer between the chorioallantoic plate and labyrinth is completely absent

cardiovascular system

abnormal placenta vasculature ( J:83560 )

• vascular development in the chorioallantoic plate is retarded

Genotype
MGI:2663660

ht2

• Allelic Composition: Pdgfra^{tm10(Pdgfra/tor)Sor}/Pdgfra^{tm11(EGFP)Sor}
• Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

mortality/aging

prenatal lethality, complete penetrance ( J:83560 )

embryo

abnormal placenta development ( J:83560 )

• the epithelial cell layer between the chorioallantoic plate and labyrinth is completely absent

Genotype
MGI:2663664

ht3

• Allelic Composition: Pdgfra^{tm9(Pdgfra/Fgfr1)Sor}/Pdgfra^{tm11(EGFP)Sor}
• Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:83560 )

• no embryos recovered after E10.5

embryo

failure of initiation of embryo turning ( J:83560 )

failure of somite differentiation ( J:83560 )

• inhibition of somitogenesis

Genotype
MGI:3694484

ht4

• Allelic Composition: Pdgfra^tm6Sor/Pdgfra^{tm11(EGFP)Sor}
• Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)

nervous system

abnormal oligodendrocyte morphology ( J:73817 )

• oligodendrocyte progenitor cell (OPC) migration away from their point of origin in the ventricular zone is inhibited between E12.5 and E13.5; although some OPCs eventually migrate out from the ventricular zone, they fail to evenly populate the spinal cord by the end of embryogenesis when myelination begins

decreased oligodendrocyte progenitor number ( J:73817 )

• the oligodendrocyte progenitor cell population is reduced throughout embryogenesis

cellular

abnormal oligodendrocyte morphology ( J:73817 )

• oligodendrocyte progenitor cell (OPC) migration away from their point of origin in the ventricular zone is inhibited between E12.5 and E13.5; although some OPCs eventually migrate out from the ventricular zone, they fail to evenly populate the spinal cord by the end of embryogenesis when myelination begins

decreased oligodendrocyte progenitor number ( J:73817 )

• the oligodendrocyte progenitor cell population is reduced throughout embryogenesis

Genotype
MGI:3694482

ht5

• Allelic Composition: Pdgfra^tm5Sor/Pdgfra^{tm11(EGFP)Sor}
• Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)

nervous system

abnormal oligodendrocyte morphology ( J:73817 )

• oligodendrocyte progenitor cell (OPC) migration away from their point of origin in the ventricular zone is inhibited between E12.5 and E13.5; although some OPCs eventually migrate out from the ventricular zone, they fail to evenly populate the spinal cord by the end of embryogenesis when myelination begins

decreased oligodendrocyte progenitor number ( J:73817 )

• the oligodendrocyte progenitor cell population is reduced throughout embryogenesis

cellular

abnormal oligodendrocyte morphology ( J:73817 )

• oligodendrocyte progenitor cell (OPC) migration away from their point of origin in the ventricular zone is inhibited between E12.5 and E13.5; although some OPCs eventually migrate out from the ventricular zone, they fail to evenly populate the spinal cord by the end of embryogenesis when myelination begins

decreased oligodendrocyte progenitor number ( J:73817 )

• the oligodendrocyte progenitor cell population is reduced throughout embryogenesis

Genotype
MGI:5780588

cx6

• Allelic Composition: Gata6^tm2.2Sad/Gata6^tm2.2Sad; Pdgfra^{tm11(EGFP)Sor}/Pdgfra⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

embryo

absent primitive endoderm ( J:213580 )

Genotype
MGI:5548177

cx7

• Allelic Composition: Pdgfa^tm1Cbet/Pdgfa^tm2Cbet; Pdgfra^{tm11(EGFP)Sor}/Pdgfra⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

respiratory system

abnormal lung morphology ( J:205009 )

• progressive dilated distal airway

abnormal pulmonary alveolus morphology ( J:205009 )

• progressive loss

emphysema ( J:205009 )

• at 3 months

digestive/alimentary system

digestive/alimentary phenotype ( J:205009 )

N • mice exhibit normal gastrointestinal tract

renal/urinary system

renal/urinary system phenotype ( J:205009 )

N • mice exhibit normal kidneys

skeleton

skeleton phenotype ( J:205009 )

N • mice exhibit normal skeleton

Genotype
MGI:4941631

cx8

• Allelic Composition: Hoxa5^tm1Rob/Hoxa5^tm1Rob; Pdgfra^{tm11(EGFP)Sor}/Pdgfra⁺
• Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * MF1

respiratory system

abnormal pulmonary alveolar parenchyma morphology ( J:113378 )

• at E16.5, most alveolar myofibroblast progenitors fail to spread distally and remain clustered around the epithelium, unlike in wild-type lungs where progenitors are dispersed in the lung parenchyma

• alveolar myofibroblast progenitors also fail to invade some regions of the developing lung

cellular

abnormal cell migration ( J:113378 )

• wounding assays performed on primary mesenchymal cells isolated from E15.5 lungs revealed that, unlike wild-type cells which invade the wounded area within 12 hrs and fill the gap by 24 hrs, mutant cells display reduced migration at both time points

• however, no difference in migratory behavior is observed in response to gelatin in Boyden chambers