All Phenotypes Pdgfra<tm11(EGFP)Sor> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pdgfra^{tm11(EGFP)Sor}
targeted mutation 11, Philippe Soriano
MGI:2663656

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdgfra^{tm11(EGFP)Sor}/Pdgfra^{tm11(EGFP)Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:5519063
ht2	Pdgfra^{tm10(Pdgfra/tor)Sor}/Pdgfra^{tm11(EGFP)Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:2663660
ht3	Pdgfra^{tm9(Pdgfra/Fgfr1)Sor}/Pdgfra^{tm11(EGFP)Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:2663664
ht4	Pdgfra^tm6Sor/Pdgfra^{tm11(EGFP)Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)	MGI:3694484
ht5	Pdgfra^tm5Sor/Pdgfra^{tm11(EGFP)Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)	MGI:3694482
cx6	Gata6^tm2.2Sad/Gata6^tm2.2Sad Pdgfra^{tm11(EGFP)Sor}/Pdgfra⁺	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ	MGI:5780588
cx7	Pdgfa^tm1Cbet/Pdgfa^tm2Cbet Pdgfra^{tm11(EGFP)Sor}/Pdgfra⁺	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6	MGI:5548177
cx8	Hoxa5^tm1Rob/Hoxa5^tm1Rob Pdgfra^{tm11(EGFP)Sor}/Pdgfra⁺	involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * MF1	MGI:4941631

Allelic Composition	Pdgfra^{tm11(EGFP)Sor}/Pdgfra^{tm11(EGFP)Sor}
Genetic Background	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfra^{tm11(EGFP)Sor} mutation (1 available); any Pdgfra mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:83560 )

embryo

abnormal placenta vasculature ( J:83560 )

• vascular development in the chorioallantoic plate is retarded

abnormal placenta development ( J:83560 )

• the epithelial cell layer between the chorioallantoic plate and labyrinth is completely absent

cardiovascular system

abnormal placenta vasculature ( J:83560 )

• vascular development in the chorioallantoic plate is retarded

Allelic Composition	Pdgfra^{tm10(Pdgfra/tor)Sor}/Pdgfra^{tm11(EGFP)Sor}
Genetic Background	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfra^{tm10(Pdgfra/tor)Sor} mutation (0 available); any Pdgfra mutation (85 available)
Pdgfra^{tm11(EGFP)Sor} mutation (1 available); any Pdgfra mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:83560 )

embryo

abnormal placenta development ( J:83560 )

• the epithelial cell layer between the chorioallantoic plate and labyrinth is completely absent

Allelic Composition	Pdgfra^{tm9(Pdgfra/Fgfr1)Sor}/Pdgfra^{tm11(EGFP)Sor}
Genetic Background	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfra^{tm11(EGFP)Sor} mutation (1 available); any Pdgfra mutation (85 available)
Pdgfra^{tm9(Pdgfra/Fgfr1)Sor} mutation (0 available); any Pdgfra mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:83560 )

• no embryos recovered after E10.5

embryo

failure of initiation of embryo turning ( J:83560 )

failure of somite differentiation ( J:83560 )

• inhibition of somitogenesis

Allelic Composition	Pdgfra^tm6Sor/Pdgfra^{tm11(EGFP)Sor}
Genetic Background	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfra^{tm11(EGFP)Sor} mutation (1 available); any Pdgfra mutation (85 available)
Pdgfra^tm6Sor mutation (0 available); any Pdgfra mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased oligodendrocyte progenitor number ( J:73817 )

• the oligodendrocyte progenitor cell population is reduced throughout embryogenesis

abnormal oligodendrocyte morphology ( J:73817 )

• oligodendrocyte progenitor cell (OPC) migration away from their point of origin in the ventricular zone is inhibited between E12.5 and E13.5; although some OPCs eventually migrate out from the ventricular zone, they fail to evenly populate the spinal cord by the end of embryogenesis when myelination begins

cellular

decreased oligodendrocyte progenitor number ( J:73817 )

• the oligodendrocyte progenitor cell population is reduced throughout embryogenesis

Allelic Composition	Pdgfra^tm5Sor/Pdgfra^{tm11(EGFP)Sor}
Genetic Background	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfra^{tm11(EGFP)Sor} mutation (1 available); any Pdgfra mutation (85 available)
Pdgfra^tm5Sor mutation (1 available); any Pdgfra mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased oligodendrocyte progenitor number ( J:73817 )

• the oligodendrocyte progenitor cell population is reduced throughout embryogenesis

abnormal oligodendrocyte morphology ( J:73817 )

cellular

decreased oligodendrocyte progenitor number ( J:73817 )

• the oligodendrocyte progenitor cell population is reduced throughout embryogenesis

Allelic Composition	Gata6^tm2.2Sad/Gata6^tm2.2Sad Pdgfra^{tm11(EGFP)Sor}/Pdgfra⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6^tm2.2Sad mutation (0 available); any Gata6 mutation (32 available)
Pdgfra^{tm11(EGFP)Sor} mutation (1 available); any Pdgfra mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

absent primitive endoderm ( J:213580 )

Allelic Composition	Pdgfa^tm1Cbet/Pdgfa^tm2Cbet Pdgfra^{tm11(EGFP)Sor}/Pdgfra⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfa^tm1Cbet mutation (0 available); any Pdgfa mutation (19 available)
Pdgfa^tm2Cbet mutation (1 available); any Pdgfa mutation (19 available)
Pdgfra^{tm11(EGFP)Sor} mutation (1 available); any Pdgfra mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal lung morphology ( J:205009 )

• progressive dilated distal airway

abnormal pulmonary alveolus morphology ( J:205009 )

• progressive loss

emphysema ( J:205009 )

• at 3 months

digestive/alimentary system

digestive/alimentary phenotype ( J:205009 )

N	• mice exhibit normal gastrointestinal tract

renal/urinary system

renal/urinary system phenotype ( J:205009 )

N	• mice exhibit normal kidneys

skeleton

skeleton phenotype ( J:205009 )

N	• mice exhibit normal skeleton

Allelic Composition	Hoxa5^tm1Rob/Hoxa5^tm1Rob Pdgfra^{tm11(EGFP)Sor}/Pdgfra⁺
Genetic Background	involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa5^tm1Rob mutation (1 available); any Hoxa5 mutation (27 available)
Pdgfra^{tm11(EGFP)Sor} mutation (1 available); any Pdgfra mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal pulmonary alveolar parenchyma morphology ( J:113378 )

• at E16.5, most alveolar myofibroblast progenitors fail to spread distally and remain clustered around the epithelium, unlike in wild-type lungs where progenitors are dispersed in the lung parenchyma

• alveolar myofibroblast progenitors also fail to invade some regions of the developing lung

cellular

abnormal cell migration ( J:113378 )

• wounding assays performed on primary mesenchymal cells isolated from E15.5 lungs revealed that, unlike wild-type cells which invade the wounded area within 12 hrs and fill the gap by 24 hrs, mutant cells display reduced migration at both time points

• however, no difference in migratory behavior is observed in response to gelatin in Boyden chambers

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