Analysis Tools
mortality/aging
|
• most mutant embryos die by E15.5 but a small percentage (9%) survive to E18.5
|
cardiovascular system
| N |
• angiogenesis is normal and hemorrhaging is rarely present
|
|
• mutants exhibiting severe facial clefting show incomplete septa formation; mutants with little facial clefting do not display septation defects
|
craniofacial
cleft palate
(
J:83560
)
|
• late-stage fetuses display a cleft face or palate
|
|
• 10% of mutant embryos exhibit severe facial clefting, but remaining mutants display lesser degree of facial clefting compared to Pdgfra-null mutants
|
skeleton
|
• ribs do not fuse at the midline and thus do not form the sternum
|
|
• failure of ribs to fuse at the midline
|
nervous system
|
• late-stage fetuses show failed ventral closure
|
spina bifida
(
J:83560
)
|
• late-stage fetuses show failed ventral closure and spina bifida, although defects are less severe than in Pdgfra null mice
|
homeostasis/metabolism
|
• edema is detected only in very-late stage (E17) mutants
|
digestive/alimentary system
cleft palate
(
J:83560
)
|
• late-stage fetuses display a cleft face or palate
|
embryo
|
• late-stage fetuses show failed ventral closure
|
spina bifida
(
J:83560
)
|
• late-stage fetuses show failed ventral closure and spina bifida, although defects are less severe than in Pdgfra null mice
|
growth/size/body
cleft palate
(
J:83560
)
|
• late-stage fetuses display a cleft face or palate
|
|
• 10% of mutant embryos exhibit severe facial clefting, but remaining mutants display lesser degree of facial clefting compared to Pdgfra-null mutants
|
