All Phenotypes Pdgfra<tm9(Pdgfra/Fgfr1)Sor> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Pdgfra^{tm9(Pdgfra/Fgfr1)Sor}/Pdgfra⁺	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:2663640
ht2	Pdgfra^{tm9(Pdgfra/Fgfr1)Sor}/Pdgfra^{tm11(EGFP)Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:2663664

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

ectopic cranial bone ( J:83560 )

• abnormal cranial bone development which results in bone growth in front of the developing eye

cleft palate ( J:83560 )

embryo

open neural tube ( J:83560 )

• failed ventral closure

spina bifida ( J:83560 )

enlarged placenta ( J:83560 )

• large placenta

abnormal trophoblast layer morphology ( J:83560 )

• trophoblast lineages are disorganized, as indicated by an expansion of the chorioallantoic layer into the surrounding labyrinth trophoblast layer

limbs/digits/tail

polydactyly ( J:83560 )

skeleton

ectopic cranial bone ( J:83560 )

• abnormal cranial bone development which results in bone growth in front of the developing eye

abnormal pubis morphology ( J:83560 )

• ectopic bone growth extending from the pubic bone and fusing, in most cases, to the elbow

rib fusion ( J:83560 )

nervous system

open neural tube ( J:83560 )

• failed ventral closure

spina bifida ( J:83560 )

digestive/alimentary system

cleft palate ( J:83560 )

growth/size/body

cleft palate ( J:83560 )

Allelic Composition	Pdgfra^{tm9(Pdgfra/Fgfr1)Sor}/Pdgfra^{tm11(EGFP)Sor}
Genetic Background	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfra^{tm11(EGFP)Sor} mutation (1 available); any Pdgfra mutation (85 available)
Pdgfra^{tm9(Pdgfra/Fgfr1)Sor} mutation (0 available); any Pdgfra mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:83560 )

• no embryos recovered after E10.5

embryo

failure of initiation of embryo turning ( J:83560 )

failure of somite differentiation ( J:83560 )

• inhibition of somitogenesis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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