Phenotypes associated with this allele

• Allele Symbol: Lnpk⁺
• Allele Name: wild type
• Allele ID: MGI:2663627
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Lnpk^Ul/Lnpk^+	B6EiC3-+ a/Lnpk^Ul A/J	MGI:3707364
ht2	Lnpk^Ul/Lnpk^+	involves: 101/H * C3H/HeJ	MGI:3582529
ht3	Lnpk^Ul/Lnpk^+	involves: 101/H * C3H/HeJ * C57BL/6J	MGI:3582532
ht4	Lnpk^Ul/Lnpk^+	involves: C3H/HeJ * C57BL/6J * FVB/N	MGI:4361308

Genotype
MGI:3707364

ht1

• Allelic Composition: Lnpk^Ul/Lnpk⁺
• Genetic Background: B6EiC3-+ a/Lnpk^Ul A/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased bleeding time ( J:31800 )

• bleeding time is increased 2.6- to 3-fold compared to controls

• platelet numbers and function appear normal

Genotype
MGI:3582529

ht2

• Allelic Composition: Lnpk^Ul/Lnpk⁺
• Genetic Background: involves: 101/H * C3H/HeJ

limbs/digits/tail

decreased radius size ( J:13461 )

• extreme reduction

short ulna ( J:13461 )

• extreme reduction

abnormal fibula morphology ( J:13461 )

• deformities

abnormal tibia morphology ( J:13461 )

• deformities

skeleton

decreased radius size ( J:13461 )

• extreme reduction

short ulna ( J:13461 )

• extreme reduction

abnormal fibula morphology ( J:13461 )

• deformities

abnormal tibia morphology ( J:13461 )

• deformities

reproductive system

male infertility ( J:13461 )

♂ • males do not breed

Genotype
MGI:3582532

ht3

• Allelic Composition: Lnpk^Ul/Lnpk⁺
• Genetic Background: involves: 101/H * C3H/HeJ * C57BL/6J

limbs/digits/tail

decreased radius size ( J:10491 )

• extreme reduction

short ulna ( J:10491 )

• extreme reduction

abnormal fibula morphology ( J:10491 )

• fibula is rotated 90 degrees

• fibula is detached from the tibia proximally

short fibula ( J:10491 )

abnormal tibia morphology ( J:10491 )

• rotated 90 degrees

bowed tibia ( J:10491 )

abnormal metacarpal bone morphology ( J:10491 )

• articulations to distal ends of long bones are abnormal

abnormal metatarsal bone morphology ( J:10491 )

• articulations to distal ends of long bones are abnormal

skeleton

decreased radius size ( J:10491 )

• extreme reduction

short ulna ( J:10491 )

• extreme reduction

abnormal fibula morphology ( J:10491 )

• fibula is rotated 90 degrees

• fibula is detached from the tibia proximally

short fibula ( J:10491 )

abnormal tibia morphology ( J:10491 )

• rotated 90 degrees

bowed tibia ( J:10491 )

abnormal metacarpal bone morphology ( J:10491 )

• articulations to distal ends of long bones are abnormal

abnormal metatarsal bone morphology ( J:10491 )

• articulations to distal ends of long bones are abnormal

reproductive system

male infertility ( J:10491 )

♂ • males do not breed although females breed well

♂ • spermatogenesis unimpaired

Genotype
MGI:4361308

ht4

• Allelic Composition: Lnpk^Ul/Lnpk⁺
• Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/N

mortality/aging

postnatal lethality ( J:37225 )

• Background Sensitivity: at weaning there are fewer heterozygotes, both male and female, than expeted from heterozygote x FVB/N matings on a predominantly FVB/N background, but not on a predominantly MOLF/Ei background