Phenotypes associated with this allele

• Allele Symbol: Chrm5^tm1Yeo
• Allele Name: targeted mutation 1, John Yeomans
• Allele ID: MGI:2661114
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chrm5^tm1Yeo/Chrm5^tm1Yeo	involves: 129X1/SvJ * CD-1	MGI:4429954
hm2	Chrm5^tm1Yeo/Chrm5^tm1Yeo	Not Specified	MGI:2661124

Genotype
MGI:4429954

hm1

• Allelic Composition: Chrm5^tm1Yeo/Chrm5^tm1Yeo
• Genetic Background: involves: 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to addictive substance ( J:134260 )

• amphetamine-treated mice fail to produce ultrasonic vocalizations unlike similarly treated wild-type mice

decreased vocalization ( J:134260 )

• the total number of frequency-modulated ultrasonic vocalizations is reduced 80% compared to in wild-type mice

• total ultrasonic vocalizations and frequency-modulated decrease in a time-dependent manner unlike in wild-type mice

• however, flat ultrasonic vocalizations are normal as are the duration and bandwidths of ultrasonic vocalizations

• amphetamine-treated mice fail to produce ultrasonic vocalizations unlike similarly treated wild-type mice

• mice exhibit decreased peak frequency of ultrasonic vocalization compared with wild-type mice

Genotype
MGI:2661124

hm2

• Allelic Composition: Chrm5^tm1Yeo/Chrm5^tm1Yeo
• Genetic Background: Not Specified

behavior/neurological

hyperdipsia ( J:83217 )

• increased drinking following food and water deprivation, relative to wild-type

endocrine/exocrine glands

decreased salivation ( J:83217 )

• decreased sustained salivation in response to pilocarpine

digestive/alimentary system

decreased salivation ( J:83217 )

• decreased sustained salivation in response to pilocarpine

homeostasis/metabolism

decreased salivation ( J:83217 )

• decreased sustained salivation in response to pilocarpine