Analysis Tools
hematopoietic system
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• bone marrow derived macrophages exhibit a decrease in ability to engulf apoptotic cells
• phagocytosis of injected apoptotic thymocytes by splenic macrophages is about 1/3 less than by wild-type macrophages indicating impaired engulfment
• spleens have many undigested apoptotic cells
• splenic red pulp macrophages isolated from mutants exhibit a defect in ability to take up dead red blood cells in vitro
• splenic macrophages in vivo show attenuated phagocytosis of injected dead red blood cells
• however, numbers of red pulp splenic macrophages are normal
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• mice develop age-dependent splenomegaly associated with increased numbers of splenocytes
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• spleens are about 1.6-fold heavier at 40 weeks of age
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• the ratio of CD4/CD8-T cells is increased, with a decrease in the CD8-T cell population
• the ratio of CD62Llo/CD62Lhi cells among the CD8+ memory T-cell population is increased
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• nave T cells (CD44lo and CD62Lhi) are decreased
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• decrease in the CD8-positive T cell population
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• memory T cells (CD44hi) are increased
• the ratio of CD62Llo/CD62Lhi cells among the CD8+ memory T-cell population is increased
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• splenic iron concentrations are increased with an increase in iron accumulation in the spleen red pulp
• mice injected with phenylhydrazine to induce acute hemolysis or mice that undergo phlebotomy to induce acute anemia exhibit more iron deposition in the spleen than wild-type mice
• however, serum iron parameters and life spans of red blood cells are normal
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• white pulp in the spleen in enlarged
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• increase in IgG deposition in the kidney of aged mice
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homeostasis/metabolism
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• splenic iron concentrations are increased with an increase in iron accumulation in the spleen red pulp
• mice injected with phenylhydrazine to induce acute hemolysis or mice that undergo phlebotomy to induce acute anemia exhibit more iron deposition in the spleen than wild-type mice
• however, serum iron parameters and life spans of red blood cells are normal
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immune system
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• bone marrow derived macrophages exhibit a decrease in ability to engulf apoptotic cells
• phagocytosis of injected apoptotic thymocytes by splenic macrophages is about 1/3 less than by wild-type macrophages indicating impaired engulfment
• spleens have many undigested apoptotic cells
• splenic red pulp macrophages isolated from mutants exhibit a defect in ability to take up dead red blood cells in vitro
• splenic macrophages in vivo show attenuated phagocytosis of injected dead red blood cells
• however, numbers of red pulp splenic macrophages are normal
|
|
• mice develop age-dependent splenomegaly associated with increased numbers of splenocytes
|
|
• spleens are about 1.6-fold heavier at 40 weeks of age
|
|
• the ratio of CD4/CD8-T cells is increased, with a decrease in the CD8-T cell population
• the ratio of CD62Llo/CD62Lhi cells among the CD8+ memory T-cell population is increased
|
|
• nave T cells (CD44lo and CD62Lhi) are decreased
|
|
• decrease in the CD8-positive T cell population
|
|
• memory T cells (CD44hi) are increased
• the ratio of CD62Llo/CD62Lhi cells among the CD8+ memory T-cell population is increased
|
|
• splenic iron concentrations are increased with an increase in iron accumulation in the spleen red pulp
• mice injected with phenylhydrazine to induce acute hemolysis or mice that undergo phlebotomy to induce acute anemia exhibit more iron deposition in the spleen than wild-type mice
• however, serum iron parameters and life spans of red blood cells are normal
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• white pulp in the spleen in enlarged
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• increase in IgG deposition in the kidney of aged mice
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• 40 week old mice exhibit increased anti-dsDNA antibody levels
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• mesangial expansion in aged mice indicating glomerulonephritis
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renal/urinary system
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• mesangial expansion in aged mice indicating glomerulonephritis
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• mesangial expansion in aged mice
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cellular
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• bone marrow derived macrophages exhibit a decrease in ability to engulf apoptotic cells
• phagocytosis of injected apoptotic thymocytes by splenic macrophages is about 1/3 less than by wild-type macrophages indicating impaired engulfment
• spleens have many undigested apoptotic cells
• splenic red pulp macrophages isolated from mutants exhibit a defect in ability to take up dead red blood cells in vitro
• splenic macrophages in vivo show attenuated phagocytosis of injected dead red blood cells
• however, numbers of red pulp splenic macrophages are normal
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growth/size/body
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• mice develop age-dependent splenomegaly associated with increased numbers of splenocytes
|
|
• spleens are about 1.6-fold heavier at 40 weeks of age
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