Phenotypes associated with this allele

• Allele Symbol: Sp7⁺
• Allele Name: wild type
• Allele ID: MGI:2656918
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Sp7^em1(IMPC)Ccpcz/Sp7^+	C57BL/6NCrl-Sp7^em1(IMPC)Ccpcz/Ccpcz	MGI:8176296
cx2	Sp7^tm1.1Rnis/Sp7^+ Zfhx4^tm1.1Rnis/Zfhx4^tm1.1Rnis	involves: C57BL * C57BL/6NCrlj * CBA/JNCrlj * DBA	MGI:7344366

Genotype
MGI:8176296

ht1

• Allelic Composition: Sp7^{em1(IMPC)Ccpcz}/Sp7⁺
• Genetic Background: C57BL/6NCrl-Sp7^{em1(IMPC)Ccpcz}/Ccpcz

Data Sources

IMPC Data for Sp7

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal spleen morphology ( J:211773 )

♂

IMPC - CCP-IMG

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:211773 )

IMPC - CCP-IMG

immune system

abnormal spleen morphology ( J:211773 )

♂

IMPC - CCP-IMG

Genotype
MGI:7344366

cx2

• Allelic Composition: Sp7^tm1.1Rnis/Sp7⁺; Zfhx4^tm1.1Rnis/Zfhx4^tm1.1Rnis
• Genetic Background: involves: C57BL * C57BL/6NCrlj * CBA/JNCrlj * DBA

skeleton

decreased chondrocyte number ( J:316165 )

• decrease in the number of hypertrophic chondrocytes at E16.5 that is more sever compared to mutant mice wild-type for Sp7

abnormal endochondral bone ossification ( J:316165 )

• impairment of calcification of the femur is more sever at E16.5 compared to mutant mice wild-type for Sp7