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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Socs1tm3Wehi
targeted mutation 3, Walter and Eliza Hall Institute of Medical Research
MGI:2656917
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Socs1tm3Wehi/Socs1tm3Wehi C57BL/6-Socs1tm3Wehi MGI:2656986
cn2
 		Socs1tm1Wehi/Socs1tm3Wehi
Tg(Lck-cre)I57Jxm/0 		involves: 129P2/OlaHsd * C57BL/6 * ICR MGI:2656984


Genotype
MGI:2656986
hm1
Allelic
Composition		 Socs1tm3Wehi/Socs1tm3Wehi
Genetic
Background		 C57BL/6-Socs1tm3Wehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs1tm3Wehi mutation (2 available); any Socs1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:83009 )
• mice are viable and fertile




Genotype
MGI:2656984
cn2
Allelic
Composition		 Socs1tm1Wehi/Socs1tm3Wehi
Tg(Lck-cre)I57Jxm/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs1tm1Wehi mutation (3 available); any Socs1 mutation (29 available)
Socs1tm3Wehi mutation (2 available); any Socs1 mutation (29 available)
Tg(Lck-cre)I57Jxm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
enlarged thymus medulla ( J:83009 )
• enlarged thymic medulla
thymus hyperplasia ( J:83009 )
• increase in thymus cellularity predominately due to an increase in CD8+ T cell population
abnormal T cell differentiation ( J:83009 )
• enhanced differentiation of thymocytes toward CD8+ T cells
decreased B cell number ( J:83009 )
• large reduction in the percentage of non-T cells, mostly B cells, in the lymph nodes
abnormal T cell subpopulation ratio ( J:83009 )
• increase in the ratio of mature CD8 single positive:CD4 single positive thymocytes from 1:4 to 1:1
• increase in the ratio of CD8+:CD4+ T cells in the spleen, however total numbers of T cells are unchanged
abnormal CD4-positive, alpha beta T cell morphology ( J:83009 )
• mature thymocytes, both CD4 single positive and CD8 single positive, are larger in size
increased CD4-positive, alpha-beta T cell number ( J:83009 )
• increase in CD4+ T cells in the blood
abnormal CD8-positive, alpha beta T cell morphology ( J:83009 )
• mature thymocytes, both CD4 single positive and CD8 single positive, are larger in size
increased CD8-positive, alpha-beta T cell number ( J:83009 )
• large increase in the percentage and number of CD8 single positive thymocytes at 6 weeks of age
• increase in CD8+ T cells in the blood
abnormal T cell activation ( J:83009 )
• almost all peripheral CD8+ T cells but not CD4+ T cells appear as CD44ho, indicating that they exhibit a memory rather than activated phenotype
lymph node hyperplasia ( J:83009 )
• lymph nodes contain 2-fold the number of cells in controls

hematopoietic system
enlarged thymus medulla ( J:83009 )
• enlarged thymic medulla
thymus hyperplasia ( J:83009 )
• increase in thymus cellularity predominately due to an increase in CD8+ T cell population
abnormal T cell differentiation ( J:83009 )
• enhanced differentiation of thymocytes toward CD8+ T cells
decreased B cell number ( J:83009 )
• large reduction in the percentage of non-T cells, mostly B cells, in the lymph nodes
abnormal T cell subpopulation ratio ( J:83009 )
• increase in the ratio of mature CD8 single positive:CD4 single positive thymocytes from 1:4 to 1:1
• increase in the ratio of CD8+:CD4+ T cells in the spleen, however total numbers of T cells are unchanged
abnormal CD4-positive, alpha beta T cell morphology ( J:83009 )
• mature thymocytes, both CD4 single positive and CD8 single positive, are larger in size
increased CD4-positive, alpha-beta T cell number ( J:83009 )
• increase in CD4+ T cells in the blood
abnormal CD8-positive, alpha beta T cell morphology ( J:83009 )
• mature thymocytes, both CD4 single positive and CD8 single positive, are larger in size
increased CD8-positive, alpha-beta T cell number ( J:83009 )
• large increase in the percentage and number of CD8 single positive thymocytes at 6 weeks of age
• increase in CD8+ T cells in the blood
abnormal T cell activation ( J:83009 )
• almost all peripheral CD8+ T cells but not CD4+ T cells appear as CD44ho, indicating that they exhibit a memory rather than activated phenotype

endocrine/exocrine glands
enlarged thymus medulla ( J:83009 )
• enlarged thymic medulla
thymus hyperplasia ( J:83009 )
• increase in thymus cellularity predominately due to an increase in CD8+ T cell population




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory