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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pdgfratm5Sor
targeted mutation 5, Philippe Soriano
MGI:2656146
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pdgfratm5Sor/Pdgfratm5Sor either: 129S4/SvJaeSor-Pdgfratm5Sor or (involves: 129S4/SvJaeSor * C57BL/6J) MGI:3694471
ht2
 		Pdgfratm5Sor/Pdgfratm11(EGFP)Sor either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J) MGI:3694482
cx3
 		Pdgfratm5Sor/Pdgfratm5Sor
Pdgfrbtm3Sor/Pdgfrbtm3Sor 		either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J) MGI:3694481


Genotype
MGI:3694471
hm1
Allelic
Composition		 Pdgfratm5Sor/Pdgfratm5Sor
Genetic
Background		 either: 129S4/SvJaeSor-Pdgfratm5Sor or (involves: 129S4/SvJaeSor * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfratm5Sor mutation (1 available); any Pdgfra mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:73817 )
• all homozygotes that survive past birth die by P16
neonatal lethality, incomplete penetrance ( J:73817 )
• majority die neonatally

growth/size/body
palatal shelves fail to meet at midline ( J:73817 )
cleft secondary palate ( J:73817 )
• 71% exhibit cleft palate, however none show midline facial or nasal clefting
decreased body size ( J:73817 )
• homozygotes that survive past birth are about 40% the size of wild-type by P16

respiratory system
abnormal pulmonary alveolus morphology ( J:73817 )
• exhibit failed alveolar septation
emphysema ( J:73817 )
• lungs are emphysematous in appearance

skeleton
abnormal pectoral girdle bone morphology ( J:73817 )
• 14 of 14 show abnormal development of the shoulder girdle
abnormal sternum morphology ( J:73817 )
• 4 of 14 show failed closure of the sternum
abnormal cervical vertebrae morphology ( J:73817 )
• 14 of 14 show cervical vertebrae malformations

craniofacial
cleft secondary palate ( J:73817 )
• 71% exhibit cleft palate, however none show midline facial or nasal clefting

nervous system
spina bifida ( J:73817 )
• 13 of 14 exhibit spina bifida
abnormal myelination ( J:73817 )
• most regions of the CNS displays severe hypomyelination

digestive/alimentary system
cleft secondary palate ( J:73817 )
• 71% exhibit cleft palate, however none show midline facial or nasal clefting

embryo
spina bifida ( J:73817 )
• 13 of 14 exhibit spina bifida




Genotype
MGI:3694482
ht2
Allelic
Composition		 Pdgfratm5Sor/Pdgfratm11(EGFP)Sor
Genetic
Background		 either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfratm11(EGFP)Sor mutation (1 available); any Pdgfra mutation (88 available)
Pdgfratm5Sor mutation (1 available); any Pdgfra mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal oligodendrocyte morphology ( J:73817 )
• oligodendrocyte progenitor cell (OPC) migration away from their point of origin in the ventricular zone is inhibited between E12.5 and E13.5; although some OPCs eventually migrate out from the ventricular zone, they fail to evenly populate the spinal cord by the end of embryogenesis when myelination begins
decreased oligodendrocyte progenitor number ( J:73817 )
• the oligodendrocyte progenitor cell population is reduced throughout embryogenesis

cellular
abnormal oligodendrocyte morphology ( J:73817 )
• oligodendrocyte progenitor cell (OPC) migration away from their point of origin in the ventricular zone is inhibited between E12.5 and E13.5; although some OPCs eventually migrate out from the ventricular zone, they fail to evenly populate the spinal cord by the end of embryogenesis when myelination begins
decreased oligodendrocyte progenitor number ( J:73817 )
• the oligodendrocyte progenitor cell population is reduced throughout embryogenesis




Genotype
MGI:3694481
cx3
Allelic
Composition		 Pdgfratm5Sor/Pdgfratm5Sor
Pdgfrbtm3Sor/Pdgfrbtm3Sor
Genetic
Background		 either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfratm5Sor mutation (1 available); any Pdgfra mutation (88 available)
Pdgfrbtm3Sor mutation (1 available); any Pdgfrb mutation (89 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
midline facial cleft ( J:73817 )
• facial clefting
embryonic growth retardation ( J:73817 )
• a proportion display earlier embryonic defects such as growth retardation

embryo
incomplete embryo turning ( J:73817 )
• in most severe cases, fail to complete turning
embryonic growth retardation ( J:73817 )
• a proportion display earlier embryonic defects such as growth retardation
open neural tube ( J:73817 )
• in most severe cases, fail to complete the fusion of the neural folds by midgestation
failure of chorioallantoic fusion ( J:73817 )
• in most severe cases, fail to complete the fusion of chorion and allantois

craniofacial
midline facial cleft ( J:73817 )
• facial clefting

nervous system
open neural tube ( J:73817 )
• in most severe cases, fail to complete the fusion of the neural folds by midgestation

skeleton

integument
fetal bleb ( J:73817 )
• blebbing along the trunk of the embryo




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory