Phenotypes associated with this allele

• Allele Symbol: Stmn1^tm1Wed
• Allele Name: targeted mutation 1, Winfried Edelmann
• Allele ID: MGI:2655259
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stmn1^tm1Wed/Stmn1^tm1Wed	involves: 129P2/OlaHsd * C57BL/6	MGI:2655270

Genotype
MGI:2655270

hm1

• Allelic Composition: Stmn1^tm1Wed/Stmn1^tm1Wed
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

myopathy ( J:74496 )

• late onset; muscle fibers become irregular in diameter and are hypertrophic

normal phenotype

no abnormal phenotype detected ( J:33563 )

• young mice exhibit no detectable abnormality; development, growth rate, behavior, T cell maturation, and fertility appear comparable to controls

nervous system

abnormal nervous system morphology ( J:74496 )

• PNS lesions; prominent in optic nerve and peripheral nerves

brain lesion ( J:74496 )

• CNS lesions; most prominent in regions of the spinal cord and motor tracts

gliosis ( J:74496 )

• cellular aggregates in white matter of increasing size with age; consisted of hypertrophic astrocytes and microglia associated with demyelinated and shrunken axons

axon degeneration ( J:74496 )

• noted in large caliber axons; late onset; progressive with age

demyelination ( J:74496 )

• thin myelin sheaths; some only had myelin debris

abnormal nerve conduction ( J:74496 )

• reduction in motor nerve conduction; 28% reduction along the ventral root/sciatic nerve

cardiovascular system

abnormal vascular wound healing ( J:144737 )

• reduced neointimal formation 14 days after blood vessel injury

homeostasis/metabolism

abnormal vascular wound healing ( J:144737 )

• reduced neointimal formation 14 days after blood vessel injury