Phenotypes associated with this allele
Allelic Composition |
Grin1tm1.1Slab/Grin1+
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Genetic Background |
involves: 129P2/OlaHsd * C57BL/6J |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm1.1Slab mutation
(0 available);
any
Grin1 mutation
(64 available)
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mortality/aging
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• mice died within 6 hours of birth
• no milk uptake even after the removal of wild-type pups
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behavior/neurological
respiratory system
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm1.1Slab mutation
(0 available);
any
Grin1 mutation
(64 available)
Grin1tm2Slab mutation
(2 available);
any
Grin1 mutation
(64 available)
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mortality/aging
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• mice died within 1 hour of birth
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homeostasis/metabolism
respiratory system
nervous system
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• absence of whisker-related patterning in the brainstem trigeminal complex
• however, no difference is seen between external brain morphology or weight relative to control mice
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• absence of patterned synapses of trigeminal afferents and their target cells (barrelettes)
• normal topographic mapping of primary trigeminal afferents
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• NMDA receptors are functional but lack coincidence detection properties
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