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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Foxp3tm1Ayr
targeted mutation 1, Alexander Y Rudensky
MGI:2654935
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Foxp3tm1Ayr/Foxp3tm1Ayr involves: 129S1/Sv * 129X1/SvJ MGI:2654942
cn2
 		Foxp3tm1Ayr/Foxp3tm1Ayr
Foxn1tm3(cre)Nrm/Foxn1+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3758964
cn3
 		Foxp3tm1Ayr/Foxp3tm1Ayr
Tg(Cd4-cre)1Cwi/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:3758965
cn4
 		Foxp3tm1Ayr/Y
Tg(Cd4-cre)1Cwi/0 		involves: C57BL/6 * DBA/2 MGI:3574971


Genotype
MGI:2654942
hm1
Allelic
Composition		 Foxp3tm1Ayr/Foxp3tm1Ayr
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm1Ayr mutation (0 available); any Foxp3 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:82560 )
• homozygotes develop normally with no signs of autoimmunity




Genotype
MGI:3758964
cn2
Allelic
Composition		 Foxp3tm1Ayr/Foxp3tm1Ayr
Foxn1tm3(cre)Nrm/Foxn1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1tm3(cre)Nrm mutation (7 available); any Foxn1 mutation (106 available)
Foxp3tm1Ayr mutation (0 available); any Foxp3 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:125405 )
N
• mice remain healthy with no signs of abnormal immune system morphology, T cell activation, tissue pathology or wasting disease




Genotype
MGI:3758965
cn3
Allelic
Composition		 Foxp3tm1Ayr/Foxp3tm1Ayr
Tg(Cd4-cre)1Cwi/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm1Ayr mutation (0 available); any Foxp3 mutation (55 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:125405 )
• the number of CD44+CD25- DN1 cells is increased

hematopoietic system
abnormal T cell differentiation ( J:125405 )
• the number of CD44+CD25- DN1 cells is increased

endocrine/exocrine glands




Genotype
MGI:3574971
cn4
Allelic
Composition		 Foxp3tm1Ayr/Y
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm1Ayr mutation (0 available); any Foxp3 mutation (55 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:97029 )
enlarged spleen ( J:97029 )

hematopoietic system

immune system
enlarged lymph nodes ( J:97029 )
• hemizygous males exhibited increased lymph node cellularity at 14 days of age compared to controls
increased susceptibility to autoimmune disorder ( J:97029 )
• hemizygous males developed lymphoproliferative autoimmune syndrome
dermatitis ( J:97029 )
• hemizygous males exhibited severe exfoliative dermatitis

integument
dermatitis ( J:97029 )
• hemizygous males exhibited severe exfoliative dermatitis




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory