All Phenotypes Epha4<tm1Kldr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Epha4^tm1Kldr
targeted mutation 1, Klas Kullander
MGI:2654411

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Epha4^tm1Kldr/Epha4^tm1Kldr	involves: 129S/SvEv * C57BL/6	MGI:3608667
hm2	Epha4^tm1Kldr/Epha4^tm1Kldr	Not Specified	MGI:2654426
ht3	Epha4^{Gt(PST038)Byg}/Epha4^tm1Kldr	involves: 129P2/OlaHsd	MGI:3823255

Allelic Composition	Epha4^tm1Kldr/Epha4^tm1Kldr
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4^tm1Kldr mutation (0 available); any Epha4 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal anterior commissure morphology ( J:101019 )

• both the anterior and posterior limbs of the anterior commissure fail to cross the midline

abnormal anterior commissure pars anterior morphology ( J:101019 )

abnormal anterior commissure pars posterior morphology ( J:101019 )

ectopic thalamus ( J:101019 )

• in 43% of homozygotes thalamic neurons are located more medially than in wild-type mice

abnormal spinal cord dorsal column morphology ( J:101019 )

• the dorsoventral extent of the dorsal funiculus is reduced and fibers within the dorsal funiculus re-cross the midline at the lumbar level

abnormal central pattern generator function ( J:101019 )

• bilateral lumbar 2 and 5 ventral roots display synchronous rather than alternating bursts in most homozygotes

Allelic Composition	Epha4^tm1Kldr/Epha4^tm1Kldr
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4^tm1Kldr mutation (0 available); any Epha4 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal gait ( J:82479 )

• rabbit like gait

nervous system

abnormal motor neuron innervation pattern ( J:82479 )

• corticospinal tract nerve fibers aberrantly cross the spinal cord midline to the contralateral side

abnormal corticospinal tract morphology ( J:82479 )

• corticospinal tract nerve fibers aberrantly cross the spinal cord midline to the contralateral side

abnormal central pattern generator function ( J:82479 )

• abnormal excitation of central pattern generators

• lumbar segments of the spinal cords of neonates exhibit synchronous left-right ventral root activity instead of the left-right alternating activity observed in wild-type after NMDA and serotonin application

• the abnormal synchronous activity can be converted to the normal alternation by antagonists of inhibitory neurotransmitters such as sarcosine

Allelic Composition	Epha4^{Gt(PST038)Byg}/Epha4^tm1Kldr
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4^{Gt(PST038)Byg} mutation (1 available); any Epha4 mutation (66 available)
Epha4^tm1Kldr mutation (0 available); any Epha4 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal motor neuron innervation pattern ( J:82479 )

• spinal cord neurons that normally express Epha4 aberrantly cross the spinal cord midline to the contralateral side

abnormal corticospinal tract morphology ( J:82479 )

• spinal cord neurons that normally express Epha4 aberrantly cross the spinal cord midline to the contralateral side

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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